KCNK15

KCNK15
Identifiers
Aliases	KCNK15 , K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1, potassium two pore domain channel subfamily K member 15
External IDs	OMIM: 607368; MGI: 2675209; HomoloGene: 11179; GeneCards: KCNK15; OMA:KCNK15 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 44,745,865 bp [1] End 44,752,313 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 163,695,571 bp [2] End 163,701,666 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic aorta ascending aorta Descending thoracic aorta left coronary artery gonad right coronary artery popliteal artery tibial arteries right uterine tube testicle Top expressed in cumulus cell olfactory bulb sternocleidomastoid muscle cerebellar cortex superior frontal gyrus submandibular gland placenta More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport cardiac conduction ion transport stabilization of membrane potential potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60598 241769 Ensembl ENSG00000124249 ENSMUSG00000035238 UniProt Q9H427 n/a RefSeq (mRNA) NM_022358 NM_001030292 RefSeq (protein) NP_071753 n/a Location (UCSC) Chr 20: 44.75 – 44.75 Mb Chr 2: 163.7 – 163.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene. ^{[5] [6] [7] [8]}

This gene encodes K_2P15.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P15.1 has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. ^[8]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000124249 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035238 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4): 923–30. doi:10.1006/bbrc.2001.5064. PMID   11409881.
6. Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B (Jun 2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J Neurophysiol. 86 (1): 130–42. doi:10.1152/jn.2001.86.1.130. PMID   11431495. S2CID   14855672.
7. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106. S2CID   7356601.
8. "Entrez Gene: KCNK15 potassium channel, subfamily K, member 15".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Karschin C, Wischmeyer E, Preisig-Müller R, et al. (2002). "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system". Mol. Cell. Neurosci. 18 (6): 632–48. doi:10.1006/mcne.2001.1045. PMID   11749039. S2CID   25284693.
• Ashmole I, Goodwin PA, Stanfield PR (2002). "TASK-5, a novel member of the tandem pore K+ channel family". Pflügers Arch. 442 (6): 828–33. doi:10.1007/s004240100620. PMID   11680614. S2CID   27704471.

External links

• KCNK15+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.