CNGB1

Last updated
CNGB1
Identifiers
Aliases CNGB1 , CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, GARP2, RCNC2, RCNCb, RCNCbeta, RP45, cyclic nucleotide gated channel beta 1, cyclic nucleotide gated channel subunit beta 1
External IDs OMIM: 600724; HomoloGene: 993; GeneCards: CNGB1; OMA:CNGB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135639
NM_001286130
NM_001297

n/a

RefSeq (protein)

NP_001129111
NP_001273059
NP_001288

n/a

Location (UCSC) Chr 16: 57.88 – 57.97 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein. [3]

Contents

See also

Related Research Articles

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<span class="mw-page-title-main">Cyclic nucleotide-binding domain</span>

Proteins that bind cyclic nucleotides share a structural domain of about 120 residues. The best studied of these proteins is the prokaryotic catabolite gene activator where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterized, one is found in rod cells where it plays a role in visual signal transduction.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000070729 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: CNGB1 cyclic nucleotide gated channel beta 1".

Further reading