GJD4

GJD4
Identifiers
Aliases	GJD4 , CX40.1, gap junction protein delta 4
External IDs	OMIM: 611922; MGI: 2444990; HomoloGene: 17692; GeneCards: GJD4; OMA:GJD4 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	35,608,935 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,282,809 bp
RNA expression pattern
	Top expressed in
	gonad; ; apex of heart; ; prefrontal cortex; ; ventricle of the heart; ; left ventricle; ; human musculoskeletal system; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; muscular system; ; muscle;
	Top expressed in
	tongue muscle; ; muscle of trunk; ; thoracic diaphragm; ; neural tube; ; autopod region; ; paraxial mesoderm; ; foot; ; hand; ; foregut; ; muscle of upper limb;
	More reference expression data
	n/a
Orthologs
	219770
	225152
	ENSG00000177291
	ENSMUSG00000036855
	Q96KN9
	Q8BSD4
	NM_153368
	NM_153086
	NP_699199
	NP_694726
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.^[5]

Function

Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177291 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036855 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: gap junction protein".
↑ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177291 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: gap junction protein".

[pmid12881038-6] Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

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