KCNH3

KCNH3
Identifiers
Aliases	KCNH3 , BEC1, ELK2, Kv12.2, potassium voltage-gated channel subfamily H member 3
External IDs	OMIM: 604527 MGI: 1341723 HomoloGene: 32150 GeneCards: KCNH3
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 49,539,030 bp [1] End 49,558,337 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F1 Start 99,122,742 bp [2] End 99,140,698 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 cingulate gyrus prefrontal cortex amygdala caudate nucleus putamen right uterine tube nucleus accumbens hippocampus proper superior frontal gyrus Top expressed in superior frontal gyrus prefrontal cortex Region I of hippocampus proper olfactory tubercle subiculum piriform cortex ciliary body cingulate gyrus oocyte primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function phosphorelay sensor kinase activity protein binding voltage-gated potassium channel activity ion channel activity potassium channel activity voltage-gated ion channel activity Cellular component intracellular anatomical structure plasma membrane integral component of membrane membrane integral component of plasma membrane Biological process phosphorelay signal transduction system signal transduction regulation of ion transmembrane transport regulation of membrane potential potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23416 16512 Ensembl ENSG00000135519 ENSMUSG00000037579 UniProt Q9ULD8 Q9WVJ0 RefSeq (mRNA) NM_001314030 NM_012284 NM_010601 RefSeq (protein) NP_001300959 NP_036416 NP_034731 Location (UCSC) Chr 12: 49.54 – 49.56 Mb Chr 15: 99.12 – 99.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene. ^{[5] [6]} The protein encoded by this gene is a voltage-gated potassium channel subunit. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000135519 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037579 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi: 10.1074/jbc.274.35.25018 . PMID   10455180.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Zou A, Lin Z, Humble M, et al. (2003). "Distribution and functional properties of human KCNH8 (Elk1) potassium channels" (PDF). Am. J. Physiol., Cell Physiol. 285 (6): C1356–66. doi:10.1152/ajpcell.00179.2003. PMID   12890647. S2CID   39591842. Archived from the original (PDF) on 2019-02-26.

External links

• Kv12.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNH3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)