CLIC2

CLIC2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PER, 2R4V, 2R5G
Identifiers
Aliases	CLIC2 , CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2
External IDs	OMIM: 300138 HomoloGene: 48010 GeneCards: CLIC2
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 155,276,211 bp [1] End 155,334,657 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon right lung spleen upper lobe of left lung gallbladder superficial temporal artery lymph node left lobe of thyroid gland right lobe of thyroid gland subcutaneous adipose tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutathione transferase activity voltage-gated ion channel activity glutathione peroxidase activity protein binding chloride channel activity Cellular component cytoplasm integral component of membrane membrane intracellular anatomical structure chloride channel complex nucleus Biological process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of ion transmembrane transport ion transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of binding chloride transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum signal transduction cellular oxidant detoxification glutathione metabolic process chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1193 n/a Ensembl ENSG00000155962 n/a UniProt O15247 n/a RefSeq (mRNA) NM_001289 n/a RefSeq (protein) NP_001280 n/a Location (UCSC) Chr X: 155.28 – 155.33 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene. ^{[3] [4]}

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti. ^[4]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000155962 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics. 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID   9339381.
4. "Entrez Gene: CLIC2 chloride intracellular channel 2".

Further reading

• Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992). "A chloride channel widely expressed in epithelial and non-epithelial cells". Nature. 356 (6364): 57–60. Bibcode:1992Natur.356...57T. doi:10.1038/356057a0. PMID   1311421. S2CID   4254798.
• Rogner UC, Heiss NS, Kioschis P, et al. (1997). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Res. 6 (10): 922–34. doi: 10.1101/gr.6.10.922 . PMID   8908511.
• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID   20226783.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex". J. Biol. Chem. 278 (18): 16262–70. doi: 10.1074/jbc.M209828200 . PMID   12601004.
• Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. 540 (1–3): 77–80. doi: 10.1016/S0014-5793(03)00228-X . PMID   12681486. S2CID   8573651.
• Board PG, Coggan M, Watson S, et al. (2005). "CLIC-2 modulates cardiac ryanodine receptor Ca²⁺ release channels". Int. J. Biochem. Cell Biol. 36 (8): 1599–612. doi:10.1016/j.biocel.2004.01.026. PMID   15147738.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID   16130169. S2CID   26007149.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• CLIC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC2 genome location and CLIC2 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.