KCNC4

For the CBS affiliate in Denver, Colorado on channel 4, see KCNC-TV.

KCNC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B4G, 1B4I, 1ZTN
Identifiers
Aliases	KCNC4 , C1orf30, HKSHIIIC, KSHIIIC, KV3.4, potassium voltage-gated channel subfamily C member 4
External IDs	OMIM: 176265 MGI: 96670 HomoloGene: 68427 GeneCards: KCNC4
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 110,210,314 bp [1] End 110,283,100 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.3|3 46.83 cM Start 107,345,619 bp [2] End 107,366,868 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cingulate gyrus prefrontal cortex amygdala dorsolateral prefrontal cortex Brodmann area 9 hypothalamus oocyte hippocampus proper thoracic aorta ascending aorta Top expressed in olfactory epithelium motor neuron vastus lateralis muscle facial motor nucleus triceps brachii muscle tibialis anterior muscle skeletal muscle tissue masseter muscle supraoptic nucleus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding Cellular component plasma membrane neuromuscular junction axon terminus voltage-gated potassium channel complex membrane integral component of membrane axon dendrite membrane neuronal cell body membrane neuronal cell body Biological process chemical synaptic transmission regulation of ion transmembrane transport regulation of neurotransmitter secretion protein homooligomerization potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3749 99738 Ensembl ENSG00000116396 ENSMUSG00000027895 UniProt Q03721 Q8R1C0 RefSeq (mRNA) NM_001039574 NM_004978 NM_153763 NM_001377330 NM_001377331 NM_145922 NM_001356447 RefSeq (protein) NP_001034663 NP_004969 NP_001364259 NP_001364260 NP_666034 NP_001343376 Location (UCSC) Chr 1: 110.21 – 110.28 Mb Chr 3: 107.35 – 107.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as K_v3.4, is a human gene. ^[5]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene. ^[5]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000116396 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027895 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4".

Further reading

• Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
• Vega-Saenz de Miera E, Moreno H, Fruhling D, et al. (1992). "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel". Proc. Biol. Sci. 248 (1321): 9–18. Bibcode:1992RSPSB.248....9V. doi:10.1098/rspb.1992.0036. PMID   1381835. S2CID   8968480.
• Ghanshani S, Pak M, McPherson JD, et al. (1992). "Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1". Genomics. 12 (2): 190–6. doi:10.1016/0888-7543(92)90365-Y. PMID   1740329.
• Rudy B, Sen K, Vega-Saenz de Miera E, et al. (1991). "Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21". J. Neurosci. Res. 29 (3): 401–12. doi:10.1002/jnr.490290316. PMID   1920536. S2CID   27662306.
• Covarrubias M, Wei A, Salkoff L, Vyas TB (1995). "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate". Neuron. 13 (6): 1403–12. doi:10.1016/0896-6273(94)90425-1. PMC   2211371 . PMID   7993631.
• Beck EJ, Sorensen RG, Slater SJ, Covarrubias M (1998). "Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action". J. Gen. Physiol. 112 (1): 71–84. doi:10.1085/jgp.112.1.71. PMC   2229409 . PMID   9649584.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Angulo E, Noé V, Casadó V, et al. (2005). "Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease". J. Neurochem. 91 (3): 547–57. doi: 10.1111/j.1471-4159.2004.02771.x . PMID   15485486.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Abbott GW, Butler MH, Goldstein SA (2006). "Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis" (PDF). FASEB J. 20 (2): 293–301. doi: 10.1096/fj.05-5070com . PMID   16449802. S2CID   21538479.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.