CACNB3

CACNB3
Identifiers
Aliases	CACNB3 , CAB3, CACNLB3, calcium voltage-gated channel auxiliary subunit beta 3
External IDs	OMIM: 601958 MGI: 103307 HomoloGene: 20187 GeneCards: CACNB3
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 48,813,794 bp [1] End 48,828,941 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 54.64 cM Start 98,528,721 bp [2] End 98,542,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence frontal pole right uterine tube endothelial cell prefrontal cortex stromal cell of endometrium amygdala cingulate gyrus dorsolateral prefrontal cortex Brodmann area 9 Top expressed in habenula superior frontal gyrus entorhinal cortex olfactory epithelium external carotid artery internal carotid artery prefrontal cortex hippocampus proper primary motor cortex olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding voltage-gated ion channel activity voltage-gated calcium channel activity high voltage-gated calcium channel activity calcium channel activity protein binding calcium channel regulator activity Cellular component apical plasma membrane membrane cytosol plasma membrane voltage-gated calcium channel complex L-type voltage-gated calcium channel complex cytoplasm Biological process membrane depolarization regulation of ion transmembrane transport ion transport regulation of voltage-gated calcium channel activity neuromuscular junction development calcium ion transmembrane transport calcium ion transport regulation of membrane repolarization during action potential calcium ion transport into cytosol protein localization to plasma membrane chemical synaptic transmission calcium ion transmembrane transport via high voltage-gated calcium channel detection of mechanical stimulus involved in sensory perception of pain positive regulation of protein targeting to membrane cellular response to oxygen-glucose deprivation negative regulation of voltage-gated calcium channel activity positive regulation of voltage-gated calcium channel activity positive regulation of high voltage-gated calcium channel activity regulation of membrane hyperpolarization negative regulation of detection of mechanical stimulus involved in sensory perception of touch positive regulation of excitatory postsynaptic potential T cell receptor signaling pathway cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 784 12297 Ensembl ENSG00000167535 ENSMUSG00000003352 UniProt P54284 P54285 RefSeq (mRNA) NM_000725 NM_001206915 NM_001206916 NM_001206917 NM_001044741 NM_001286226 NM_007581 NM_001356543 RefSeq (protein) NP_000716 NP_001193844 NP_001193845 NP_001193846 NP_001038206 NP_001273155 NP_031607 NP_001343472 Location (UCSC) Chr 12: 48.81 – 48.83 Mb Chr 15: 98.53 – 98.54 Mb PubMed search [3] [4]
Wikidata
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Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene. ^{[5] [6]}

See also

• Voltage-dependent calcium channel

References

1. GRCh38: Ensembl release 89: ENSG00000167535 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003352 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit". Eur J Biochem. 220 (1): 257–62. doi:10.1111/j.1432-1033.1994.tb18621.x. PMID   8119293.
6. "Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

Further reading

• Yamada Y, Masuda K, Li Q, et al. (1995). "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes". Genomics. 27 (2): 312–9. doi:10.1006/geno.1995.1048. PMID   7557998.
• Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen". Ann. Neurol. 33 (1): 113–20. doi:10.1002/ana.410330126. PMID   8494331. S2CID   24241609.
• Murakami M, Wissenbach U, Flockerzi V (1996). "Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products". Eur. J. Biochem. 236 (1): 138–43. doi: 10.1111/j.1432-1033.1996.t01-1-00138.x . PMID   8617257.
• Scott VE, De Waard M, Liu H, et al. (1996). "Beta subunit heterogeneity in N-type Ca2+ channels". J. Biol. Chem. 271 (6): 3207–12. doi: 10.1074/jbc.271.6.3207 . PMID   8621722.
• Bell DC, Butcher AJ, Berrow NS, et al. (2001). "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents". J. Neurophysiol. 85 (2): 816–27. doi:10.1152/jn.2001.85.2.816. PMID   11160515. S2CID   147295966.
• Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells". J. Physiol. 541 (Pt 2): 435–52. doi:10.1113/jphysiol.2002.018515. PMC   2290333 . PMID   12042350.
• Murakami M, Fleischmann B, De Felipe C, et al. (2002). "Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels". J. Biol. Chem. 277 (43): 40342–51. doi: 10.1074/jbc.M203425200 . hdl: 10261/310195 . PMID   12161429.
• Qin N, Yagel S, Momplaisir ML, et al. (2002). "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit". Mol. Pharmacol. 62 (3): 485–96. doi:10.1124/mol.62.3.485. PMID   12181424.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Chen YH, Li MH, Zhang Y, et al. (2004). "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels". Nature. 429 (6992): 675–80. Bibcode:2004Natur.429..675C. doi:10.1038/nature02641. PMID   15170217. S2CID   4422712.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Vendel AC, Terry MD, Striegel AR, et al. (2006). "Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex". J. Neurosci. 26 (10): 2635–44. doi: 10.1523/JNEUROSCI.0067-06.2006 . PMC   6675161 . PMID   16525042.

External links

• CACNB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CACNB3 genome location and CACNB3 gene details page in the UCSC Genome Browser .