CLNS1A

CLNS1A
Identifiers
Aliases	CLNS1A , CLCI, CLNS1B, ICln, chloride nucleotide-sensitive channel 1A
External IDs	OMIM: 602158; MGI: 109638; HomoloGene: 990; GeneCards: CLNS1A; OMA:CLNS1A - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q14.1 Start 77,514,936 bp [1] End 77,637,794 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 E1|7 53.57 cM Start 97,345,841 bp [2] End 97,370,003 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone Achilles tendon ganglionic eminence body of pancreas right adrenal gland right adrenal cortex left ovary C1 segment left adrenal gland monocyte Top expressed in motor neuron primitive streak medial ganglionic eminence condyle fossa vestibular membrane of cochlear duct hair follicle Rostral migratory stream renal corpuscle internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity protein binding RNA binding Cellular component plasma membrane cytoskeleton nucleoplasm nucleus methylosome pICln-Sm protein complex cytosol cytoplasm Biological process cell volume homeostasis chloride transport spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1207 12729 Ensembl ENSG00000074201 ENSMUSG00000025439 UniProt P54105 Q61189 Q923F1 RefSeq (mRNA) NM_001311202 NM_001293 NM_001311199 NM_001311200 NM_001311201 NM_023671 RefSeq (protein) NP_001284 NP_001298128 NP_001298129 NP_001298130 NP_001298131 NP_076160 Location (UCSC) Chr 11: 77.51 – 77.64 Mb Chr 7: 97.35 – 97.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene. ^{[5] [6] [7]}

Interactions

CLNS1A has been shown to interact with:

• ITGA2B, ^[8]
• PRMT5, ^{[9] [10] [11] [12]}
• SNRPD1, ^[9] and
• SNRPD3. ^[9]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000074201 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025439 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun. 208 (1): 89–95. doi: 10.1006/bbrc.1995.1309 . PMID   7887970.
6. Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics. 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID   8975725.
7. "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A".
8. Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26): 27286–93. doi: 10.1074/jbc.M402159200 . PMID   15075326.
9. Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC   99994 . PMID   11713266.
10. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (May 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. 273 (18): 10811–4. doi: 10.1074/jbc.273.18.10811 . PMID   9556550.
11. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi: 10.1074/jbc.M109984200 . PMID   11756452.
12. Krzyzanowski A, Gasper R, Adihou H, 't Hart P, Waldmann H (Feb 2021). "Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex". ChemBioChem. 22 (11): 1908–1914. doi: 10.1002/cbic.202100079 . PMC   8252068 . PMID   33624332.

Further reading

• Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. doi: 10.2741/1911 . PMID   16368544. S2CID   26325962.
• Buyse G, de Greef C, Raeymaekers L, Droogmans G, Nilius B, Eggermont J (1996). "The ubiquitously expressed pICln protein forms homomeric complexes in vitro". Biochem. Biophys. Res. Commun. 218 (3): 822–7. doi: 10.1006/bbrc.1996.0146 . PMID   8579598.
• Schwartz RS, Rybicki AC, Nagel RL (1997). "Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin". Biochem. J. 327 (2): 609–16. doi:10.1042/bj3270609. PMC   1218836 . PMID   9359436.
• Bekri S, Adélaïde J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pébusque MJ, Theillet C, Birnbaum D, Gaudray P (1998). "Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma". Cytogenet. Cell Genet. 79 (1–2): 125–31. doi:10.1159/000134699. PMID   9533029.
• Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. 273 (18): 10811–4. doi: 10.1074/jbc.273.18.10811 . PMID   9556550.
• Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation". Blood. 92 (4): 1442–7. doi:10.1182/blood.V92.4.1442. PMID   9694734.
• Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE (1999). "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins". Mol. Cell. Biol. 19 (6): 4113–20. doi:10.1128/MCB.19.6.4113. PMC   104370 . PMID   10330151.
• Hubert MD, Levitan I, Hoffman MM, Zraggen M, Hofreiter ME, Garber SS (2000). "Modulation of volume regulated anion current by I(Cln)". Biochim. Biophys. Acta. 1466 (1–2): 105–14. doi: 10.1016/S0005-2736(00)00177-2 . PMID   10825435.
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC   99994 . PMID   11713266.
• Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): 1990–4. doi:10.1016/S0960-9822(01)00592-9. hdl: 11858/00-001M-0000-0012-F501-7 . PMID   11747828. S2CID   14742376.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi: 10.1074/jbc.M109984200 . PMID   11756452.
• Meyer G, Rodighiero S, Guizzardi F, Bazzini C, Bottà G, Bertocchi C, Garavaglia L, Dossena S, Manfredi R, Sironi C, Catania A, Paulmichl M (2004). "Volume-regulated Cl⁻ channels in human pleural mesothelioma cells". FEBS Lett. 559 (1–3): 45–50. Bibcode:2004FEBSL.559...45M. doi:10.1016/S0014-5793(04)00020-1. PMID   14960305. S2CID   24747269.
• Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26): 27286–93. doi: 10.1074/jbc.M402159200 . PMID   15075326.
• Fürst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4". J. Biol. Chem. 280 (35): 31276–82. doi: 10.1074/jbc.M500541200 . PMID   15905169.
• Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J. Biol. Chem. 280 (41): 34435–40. doi: 10.1074/jbc.M505077200 . hdl: 21.11116/0000-0007-E5F1-6 . PMID   16087681.

External links

• CLNS1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLNS1A genome location and CLNS1A gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.