TRPC4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TRPC4 , HTRP-4, HTRP4, TRP4, transient receptor potential cation channel subfamily C member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603651; MGI: 109525; HomoloGene: 22955; GeneCards: TRPC4; OMA:TRPC4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene. [5] [6]
TrpC4 is a member of the transient receptor potential cation channels. This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. [7]
The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain. [8] In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra. [9]
Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders. [10] However deletion of the trpc4 gene had no impact on basic or complex strategic learning. [11] Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons, it has been proposed that it may have an important role in dopamine related processes including addiction and attention. [9]
Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. [12]
TRPC4 has been shown to interact with ITPR1, [13] [14] TRPC1, [15] [16] and TRPC5. [16]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.