ML-SA1

Last updated
ML-SA1
ML-SA1 structure.png
Identifiers
  • 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H22N2O3
Molar mass 362.429 g·mol−1
3D model (JSmol)
  • CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C
  • InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
  • Key:KDDHBJICVBONAX-UHFFFAOYSA-N

ML-SA1 is a chemical compound which acts as an "agonist" (i.e. channel opener) of the TRPML family of calcium channels. It has mainly been studied for its role in activating TRPML1 channels, although it also shows activity at the less studied TRPML2 and TRPML3 subtypes. TRPML1 is important for the function of lysosomes, and ML-SA1 has been used to study several disorders resulting from impaired lysosome function, including mucolipidosis type IV and Niemann-Pick's disease type C, [1] [2] [3] [4] as well as other conditions such as stroke and Alzheimer's disease. [5] [6]

References

  1. ↑ Feng X, Xiong J, Lu Y, Xia X, Zhu MX (December 2014). "Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1". Cell Calcium. 56 (6): 446–56. doi:10.1016/j.ceca.2014.09.004. PMC   4252876 . PMID   25266962.
  2. ↑ Erkhembaatar M, Gu DR, Lee SH, Yang YM, Park S, Muallem S, et al. (February 2017). "2+ Signaling is Essential for Osteoclastogenesis and Bone Remodeling". Journal of Bone and Mineral Research. 32 (2): 385–396. doi:10.1002/jbmr.2986. PMC   9850942 . PMID   27589205.
  3. ↑ Gómez NM, Lu W, Lim JC, Kiselyov K, Campagno KE, Grishchuk Y, et al. (February 2018). "Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation". FASEB Journal. 32 (2): 782–794. doi: 10.1096/fj.201700220RR . PMC   5888396 . PMID   29030399.
  4. ↑ Fine M, Schmiege P, Li X (October 2018). "2-mediated human TRPML1 regulation". Nature Communications. 9 (1): 4192. doi: 10.1038/s41467-018-06493-7 . PMC   6180102 . PMID   30305615.
  5. ↑ Wang Y, Jiang SW, Liu X, Niu L, Ge XL, Zhang JC, et al. (2018). "Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia". Oxidative Medicine and Cellular Longevity. 2018 4612727. doi: 10.1155/2018/4612727 . PMC   6312622 . PMID   30662583.
  6. ↑ Hui L, Soliman ML, Geiger NH, Miller NM, Afghah Z, Lakpa KL, et al. (2019). "Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis". Journal of Alzheimer's Disease. 67 (1): 393–410. doi:10.3233/JAD-180941. PMC   6425476 . PMID   30594929.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.