GSK417651A

Last updated
GSK417651A
GSK417651A structure.png
Identifiers
  • 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C20H19N3O2S
Molar mass 365.45 g·mol−1
3D model (JSmol)
  • COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3
  • InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
  • Key:NTXBDULODNTCKP-UHFFFAOYSA-N

GSK417651A is a chemical compound which acts as a blocker of the TRPC family of calcium channels, with selectivity for the TRPC3 and TRPC6 subtypes. It has been used to investigate the role of TRPC3/6 channels in heart function. [1] [2] [3]

References

  1. ↑ Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg (2013). "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104 (2): 454a. Bibcode:2013BpJ...104..454X. doi: 10.1016/j.bpj.2012.11.2513 .
  2. ↑ Wen H, Gwathmey JK, Xie LH (2020). "Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology". Frontiers in Cardiovascular Medicine. 7: 24. doi: 10.3389/fcvm.2020.00024 . PMC   7052113 . PMID   32158769.
  3. ↑ Al-Shammari H, Latif N, Sarathchandra P, McCormack A, Rog-Zielinska EA, Raja S, et al. (2020). "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE. 15 (10) e0240532. Bibcode:2020PLoSO..1540532A. doi: 10.1371/journal.pone.0240532 . PMC   7561104 . PMID   33057457.
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