Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is a chemical irritant and neurotoxin for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact. Capsaicin and several related amides (capsaicinoids) are produced as secondary metabolites by chili peppers, probably as deterrents against certain mammals and fungi. Pure capsaicin is a hydrophobic, colorless, highly pungent, crystalline solid.
Euphorbia is a very large and diverse genus of flowering plants, commonly called spurge, in the family Euphorbiaceae. "Euphorbia" is sometimes used in ordinary English to collectively refer to all members of Euphorbiaceae, not just to members of the genus.
Euphorbium, an acrid dull-yellow or brown resin, consisting of the concreted milky juice of several species of Euphorbia, cactus-like perennial plants indigenous to Morocco. It dissolves in alcohol, ether and turpentine; in water it is only slightly soluble. It consists of two or more resins and a substance euphorbone, C20H36O or C15H24O. Pliny the Elder states that the name of the drug was given to it in honor of Euphorbus, the physician of Juba II, king of Mauretania. In former times euphorbium was valued in medicine for its drastic, purgative and emetic properties.
Euphorbia tithymaloides is a perennial succulent spurge. An erect shrub, the plant is also known by the scientific name Pedilanthus tithymaloides. However, the genus Pedilanthus has been subsumed into the genus Euphorbia, and is more correctly known by its new name.
Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge, a cactus-like plant commonly found in Morocco, and in Euphorbia poissonii found in northern Nigeria. It is a potent functional analog of capsaicin, the active ingredient in chili peppers.
Euphorbia tirucalli is a tree native to Africa that grows in semi-arid tropical climates. A hydrocarbon plant, it produces a poisonous latex that can cause temporary blindness.
Euphorbia lathyris, the caper spurge or paper spurge, is a species of spurge native to southern Europe, northwest Africa, and eastward through southwest Asia to western China.
The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels. Fatty acid metabolites with affinity for this receptor are produced by cyanobacteria, which diverged from eukaryotes at least 2000 million years ago (MYA). The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1 to mediate the detection of noxious environmental stimuli.
Tinyatoxin is an analog of the neurotoxin resiniferatoxin. It occurs naturally in Euphorbia poissonii.
Euphorbia candelabrum is a succulent species of plant in the family Euphorbiaceae, one of several plants commonly known as candelabra tree. It is endemic to the Horn of Africa and eastern Africa along the East African Rift system. It is known in Ethiopia by its Amharic name, qwolqwal, or its Oromo name, adaamii. It is closely related to three other species of Euphorbia: Euphorbia ingens in the dry regions of southern Africa, Euphorbia conspicua from western Angola, and Euphorbia abyssinica, which is native to countries including Sudan, Eritrea, Djibouti, Ethiopia and Somalia.
Euphorbia poissonii, also known as Euphorbia poissoni and, incorrectly, as Euphorbia poisoni, is a highly irritant and toxic succulent member of the large and varied spurge family of plants. It is native to northern Nigeria, where local farmers extract its latex for use as a pesticide. Its powerfully irritant and pain-producing nature mandates use as a fencing plant. It is known to the Berom people of the Jos area as pyùlúp who transplant it to their compounds where it is regarded as protection against witchcraft.
Euphorbiaceae, the spurge family, is a large family of flowering plants. In English, they are also commonly called euphorbias, which is also the name of the type genus of the family. Most spurges, such as Euphorbia paralias, are herbs, but some, especially in the tropics, are shrubs or trees, such as Hevea brasiliensis. Some, such as Euphorbia canariensis, are succulent and resemble cacti because of convergent evolution. This family has a cosmopolitan global distribution. The greatest diversity of species is in the tropics; however, the Euphorbiaceae also have many species in nontropical areas of all continents except Antarctica.
Euphorbia balsamifera is a flowering plant in the spurge family Euphorbiaceae. It is distributed in the Canary Islands and the western Sahara. It is the vegetable symbol of the island of Lanzarote. Euphorbia adenensis has been treated as a subspecies of this species.
Iodoresiniferatoxin (I-RTX) is a strong competitive antagonist of the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor. I-RTX is derived from resiniferatoxin (RTX).
Relief from chronic pain remains a recognized unmet medical need. Consequently, the search for new analgesic agents is being intensively studied by the pharmaceutical industry. The TRPV1 receptor is a ligand gated ion channel that has been implicated in mediation of many types of pain and therefore studied most extensively. The first competitive antagonist, capsazepine, was first described in 1990; since then, several TRPV1 antagonists have entered clinical trials as analgesic agents. Should these new chemical entities relieve symptoms of chronic pain, then this class of compounds may offer one of the first novel mechanisms for the treatment of pain in many years.
Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. Zucapsaicin is a member of phenols and a member of methoxybenzenes. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use.
Euphorbia royleana is a species of flowering plant in the family Euphorbiaceae. It is also known as Sullu spurge, and Royle's spurge. It is a succulent and almost cactus like in appearance although unrelated. It grows right across the Himalaya mountains from Pakistan, India, Bhutan, Myanmar, Nepal to western China, It prefers dry and rocky slopes between 1000 and 1500 meters, but has been found up to 2000 meters. Flowering and fruiting is in spring to early summer (March–July) and seeding is in June–October. It is used as a hedging plant in northern India and has medicinal uses.
Euphorbia abyssinica, commonly known as the desert candle or candelabra spurge, is a species of plant in the family Euphorbiaceae. E. abyssinica is endemic to Ethiopia, Somalia, Sudan and Eritrea. It was first described in 1791, by the German botanist Johann Friedrich Gmelin. In its native habitat, it can grow up to 10 m (33 ft) tall. The woody stem is used for firewood and as timber in roofing, furniture and other items, and the sap is used in traditional medicine. It is also cultivated as an ornamental house plant.
Euphorbia missurica, commonly called prairie sandmat, or Missouri spurge, is a species of flowering plant in the spurge family (Euphorbiaceae). It is native to North America, where it is found primarily in area of the Great Plains. Its natural habitat is in dry, often calcareous areas, including glades, bluffs, and open woodlands.
