SN-2

Last updated
SN-2
SN-2 structure.png
Identifiers
  • 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C17H21NO
Molar mass 255.361 g·mol−1
3D model (JSmol)
  • CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
  • InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3
  • Key:WKLZNTYMDOPBSE-UHFFFAOYSA-N

SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related TRPML1 and TRPML2 channels. [1] It has demonstrated antiviral activity in an in vitro model. [2]

See also

References

  1. ↑ Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, et al. (February 2010). "Small molecule activators of TRPML3". Chemistry & Biology. 17 (2): 135–48. doi: 10.1016/j.chembiol.2009.12.016 . PMC   2834294 . PMID   20189104.
  2. ↑ Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID   32858116. S2CID   221365410.
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