TRPV3-74a

Last updated
TRPV3-74a
TRPV3-74a structure.png
Identifiers
  • 3-[(S)-hydroxy(pyridin-2-yl)methyl]-1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]cyclobutan-1-ol
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C17H17F3N2O2
Molar mass 338.330 g·mol−1
3D model (JSmol)
  • C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O
  • InChI=1S/C17H17F3N2O2/c1-15(24)9-16(10-15,14(23)12-4-2-3-6-21-12)13-8-11(5-7-22-13)17(18,19)20/h2-8,14,23-24H,9-10H2,1H3/t14-,15?,16?/m1/s1
  • Key:MTJXDHFAWXGXIN-QQFBHYJXSA-N

TRPV3-74a is a drug which acts as a selective antagonist for the TRPV3 calcium channel. It has analgesic effects in animal studies against both neuropathic pain and normal pain responses. [1] [2]

References

  1. ↑ Gomtsyan A, Schmidt RG, Bayburt EK, Gfesser GA, Voight EA, Daanen JF, et al. (May 2016). "Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists". Journal of Medicinal Chemistry. 59 (10): 4926–47. doi:10.1021/acs.jmedchem.6b00287. PMID   27077528.
  2. ↑ Kocienski P (February 2017). "Synthesis of a TRPV3 Antagonist". Synfacts. 13 (2): 123. doi:10.1055/s-0036-1589889. S2CID   100058677.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.