KCNC2

Last updated
KCNC2
Identifiers
Aliases KCNC2 , KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs OMIM: 176256 MGI: 96668 HomoloGene: 71199 GeneCards: KCNC2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001025581
NM_001359752
NM_001359753
NM_001379643
NM_001379644

Contents

RefSeq (protein)

NP_001020752
NP_001346681
NP_001346682
NP_001366572
NP_001366573

Location (UCSC) Chr 12: 75.04 – 75.21 Mb Chr 10: 112.11 – 112.3 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene. [5] [6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2). [7]

Expression pattern

Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells. [8] [9] [7]

Physiological role

Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation. [9] [10] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals. [7] [8]

Pharmacological properties

Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs). [7] [9] This can be useful in identifying native channels. [9]

Transcript variants

There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence. [11]

Related Research Articles

<span class="mw-page-title-main">KCNC4</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as Kv3.4, is a human gene.

<span class="mw-page-title-main">KCNC1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily C member 1 is a protein that in humans is encoded by the KCNC1 gene.

<span class="mw-page-title-main">KCNG1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 1 is a protein that in humans is encoded by the KCNG1 gene.

<span class="mw-page-title-main">KCNC3</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or Kv3.3 is a protein that in humans is encoded by the KCNC3.

<span class="mw-page-title-main">KCNA6</span> Protein-coding gene in humans

Potassium voltage-gated channel subfamily A member 6 also known as Kv1.6 is a protein that in humans is encoded by the KCNA6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNA7</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily A member 7 also known as Kv1.7 is a protein that in humans is encoded by the KCNA7 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

<span class="mw-page-title-main">KCNA10</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily A member 10 also known as Kv1.8 is a protein that in humans is encoded by the KCNA10 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNF1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the KCNF1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNG2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 2 is a protein that in humans is encoded by the KCNG2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNG3</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 3 is a protein that in humans is encoded by the KCNG3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNG4</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNV1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNV2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily V member 2 is a protein that in humans is encoded by the KCNV2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNS1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNS2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH6</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the KCNH6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH7</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily H member 7 is a protein that in humans is encoded by the KCNH7 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH8</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily H member 8 is a protein that in humans is encoded by the KCNH8 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH3</span> Protein-coding gene in humans

Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNH4</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily H member 4 is a protein that in humans is encoded by the KCNH4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166006 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035681 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID   8111118. S2CID   24121259.
  6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
  7. 1 2 3 4 Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
  8. 1 2 Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat" . Retrieved 2008-10-20.
  9. 1 2 3 4 Rudy B, McBain CJ (September 2001). "Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID   11506885. S2CID   36100588.
  10. Lien CC, Jonas P (March 2003). "Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi: 10.1523/JNEUROSCI.23-06-02058.2003 . PMC   6742035 . PMID   12657664.
  11. Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of Kv3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi: 10.1111/j.1749-6632.1999.tb11295.x . PMID   10414303. S2CID   25289187.