TRPM7

TRPM7
Identifiers
Aliases	TRPM7 , ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDs	OMIM: 605692; MGI: 1929996; HomoloGene: 9774; GeneCards: TRPM7; OMA:TRPM7 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	50,686,797 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	126,718,150 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; Achilles tendon; ; cardiac muscle tissue of right atrium; ; epithelium of colon; ; sural nerve; ; cartilage tissue; ; testicle; ; gastric mucosa; ; right lobe of liver; ; buccal mucosa cell;
	Top expressed in
	molar; ; Rostral migratory stream; ; tail of embryo; ; Gonadal ridge; ; parotid gland; ; saccule; ; epithelium of small intestine; ; pineal gland; ; atrium; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; myosin binding ; metal ion binding ; kinase activity ; protein serine/threonine kinase activity ; ion channel activity ; actin binding ; ATP binding ; calcium channel activity ;
Cellular component	integral component of membrane ; membrane ; ruffle ; plasma membrane ;
Biological process	cellular magnesium ion homeostasis ; calcium-dependent cell-matrix adhesion ; programmed cell death ; phosphorylation ; actomyosin structure organization ; cation transport ; ion transport ; protein tetramerization ; protein phosphorylation ; calcium ion transmembrane transport ; protein autophosphorylation ; necroptosis ; calcium ion transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	54822
	58800
	ENSG00000092439
	ENSMUSG00000027365
	Q96QT4
	Q923J1
	NM_001301212 ; NM_017672
	NM_001164325 ; NM_021450
	NP_001288141 ; NP_060142
	NP_001157797 ; NP_067425
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 17, 2024

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.^[5]

Interactions

TRPM7 has been shown to interact with PLCB1 ^[6] and PLCB2.^[6]

Clinical relevance

Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.^[7]^[8]

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.^[9]

Related Research Articles

Transient receptor potential channels are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC, TRPV, TRPVL, TRPM, TRPS, TRPN, and TRPA. Group 2 consists of TRPP and TRPML. Other less-well categorized TRP channels exist, including yeast channels and a number of Group 1 and Group 2 channels present in non-animals. Many of these channels mediate a variety of sensations such as pain, temperature, different kinds of taste, pressure, and vision. In the body, some TRP channels are thought to behave like microscopic thermometers and used in animals to sense hot or cold. Some TRP channels are activated by molecules found in spices like garlic (allicin), chili pepper (capsaicin), wasabi ; others are activated by menthol, camphor, peppermint, and cooling agents; yet others are activated by molecules found in cannabis or stevia. Some act as sensors of osmotic pressure, volume, stretch, and vibration. Most of the channels are activated or inhibited by signaling lipids and contribute to a family of lipid-gated ion channels.

TRPC is a family of transient receptor potential cation channels in animals.

TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin). Functional TRPM channels are believed to form tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8.

Mucolipin-1 also known as TRPML1 is a protein that in humans is encoded by the MCOLN1 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.

Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily.

Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growth, proliferation and pathological hypertrophy. These are diacylglycerol-sensitive cation channels known to regulate intracellular calcium via activation of the phospholipase C (PLC) pathway and/or by sensing Ca2+ store depletion. Together, their role in calcium homeostasis has made them potential therapeutic targets for a variety of central and peripheral pathologies.

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene. TRPV2 is a nonspecific cation channel that is a part of the TRP channel family. This channel allows the cell to communicate with its extracellular environment through the transfer of ions, and responds to noxious temperatures greater than 52 °C. It has a structure similar to that of potassium channels, and has similar functions throughout multiple species; recent research has also shown multiple interactions in the human body.

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.

Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name.

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

Transient receptor potential cation channel subfamily V member 5 is a calcium channel protein that in humans is encoded by the TRPV5 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

Mucolipin-2 also known as TRPML2 is a protein that in humans is encoded by the MCOLN2 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092439 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027365 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".
1 2 Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.
↑ Vargas-Poussou R, Claverie-Martin F, Prot-Bertoye C, Carotti V, van der Wijst J, Perdomo-Ramirez A, Fraga-Rodriguez GM, Hureaux M, Bos C, Latta F, Houillier P, Hoenderop JG, de Baaij JH (2023). "Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia". Nephrology Dialysis Transplantation. 38 (3): 679–690. doi:10.1093/ndt/gfac182. PMC 9976740 . PMID 35561741.
↑ Bosman W, Butler KM, Chang CA, Ganapathi M, Guzman E, Latta F, Chung WK, Claverie-Martin F, Davis JM, Hoenderop JG, de Baaij JH (2024). "Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay". Clinical Kidney Journal. sfae211. doi: 10.1093/ckj/sfae211 .
↑ Baldoli E, Maier JA (2012). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. doi:10.1007/s10456-011-9242-0. PMID 22183257. S2CID 16274084.

External links

TRPM7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092439 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027365 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".

[pmid11941371-6] 1 2 Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.

[doi.10.1093/ndt/gfac182-7] Vargas-Poussou R, Claverie-Martin F, Prot-Bertoye C, Carotti V, van der Wijst J, Perdomo-Ramirez A, Fraga-Rodriguez GM, Hureaux M, Bos C, Latta F, Houillier P, Hoenderop JG, de Baaij JH (2023). "Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia". Nephrology Dialysis Transplantation. 38 (3): 679–690. doi:10.1093/ndt/gfac182. PMC 9976740 . PMID 35561741.

[doi.10.1093/ckj/sfae211-8] Bosman W, Butler KM, Chang CA, Ganapathi M, Guzman E, Latta F, Chung WK, Claverie-Martin F, Davis JM, Hoenderop JG, de Baaij JH (2024). "Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay". Clinical Kidney Journal. sfae211. doi: 10.1093/ckj/sfae211 .

[doi.10.1007/s10456-011-9242-0-9] Baldoli E, Maier JA (2012). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. doi:10.1007/s10456-011-9242-0. PMID 22183257. S2CID 16274084.

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