KCNMB4

KCNMB4
Identifiers
Aliases	KCNMB4 , potassium calcium-activated channel subfamily M regulatory beta subunit 4
External IDs	OMIM: 605223; MGI: 1913272; HomoloGene: 8721; GeneCards: KCNMB4; OMA:KCNMB4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q15 Start 70,366,290 bp [1] End 70,434,292 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D2 Start 116,253,766 bp [2] End 116,309,783 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell postcentral gyrus entorhinal cortex hippocampus proper corpus callosum superior frontal gyrus middle temporal gyrus lateral nuclear group of thalamus external globus pallidus prefrontal cortex Top expressed in primary motor cortex lobe of cerebellum cingulate gyrus facial motor nucleus cerebellar vermis globus pallidus medial dorsal nucleus spermatocyte prefrontal cortex habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calcium-activated potassium channel activity potassium channel regulator activity Cellular component integral component of membrane integral component of plasma membrane plasma membrane voltage-gated potassium channel complex membrane Biological process ion transport action potential neuronal action potential regulation of vasoconstriction chemical synaptic transmission detection of calcium ion potassium ion transport regulation of neurotransmitter secretion potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27345 58802 Ensembl ENSG00000135643 ENSMUSG00000054934 UniProt Q86W47 Q9JIN6 RefSeq (mRNA) NM_014505 NM_021452 RefSeq (protein) NP_055320 NP_067427 Location (UCSC) Chr 12: 70.37 – 70.43 Mb Chr 10: 116.25 – 116.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene. ^{[5] [6] [7]}

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. ^[7]

See also

• BK channel
• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000135643 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054934 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000). "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4". J Biol Chem. 275 (9): 6453–61. doi: 10.1074/jbc.275.9.6453 . PMID   10692449.
6. Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family". FEBS Lett. 474 (1): 99–106. Bibcode:2000FEBSL.474...99B. doi:10.1016/S0014-5793(00)01584-2. PMID   10828459. S2CID   32791798.
7. "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4".

Further reading

• Orio P, Rojas P, Ferreira G, Latorre R (2002). "New disguises for an old channel: MaxiK channel beta-subunits". News Physiol. Sci. 17 (4): 156–61. doi:10.1152/nips.01387.2002. hdl: 10533/173696 . PMID   12136044.
• Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi: 10.1073/pnas.090521697 . PMC   18318 . PMID   10758170.
• Meera P, Wallner M, Toro L (2000). "A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5562–7. Bibcode:2000PNAS...97.5562M. doi: 10.1073/pnas.100118597 . PMC   25868 . PMID   10792058.
• Weiger TM, Holmqvist MH, Levitan IB, et al. (2000). "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels". J. Neurosci. 20 (10): 3563–70. doi:10.1523/JNEUROSCI.20-10-03563.2000. PMC   6772688 . PMID   10804197.
• Jin P, Weiger TM, Wu Y, Levitan IB (2002). "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit". J. Biol. Chem. 277 (12): 10014–20. doi: 10.1074/jbc.M107682200 . PMID   11790768.
• Jin P, Weiger TM, Levitan IB (2003). "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels". J. Biol. Chem. 277 (46): 43724–9. doi: 10.1074/jbc.M205795200 . PMID   12223479.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.