HCN3

HCN3
Identifiers
Aliases	HCN3 , hyperpolarization activated cyclic nucleotide gated potassium channel 3
External IDs	OMIM: 609973 MGI: 1298211 HomoloGene: 22453 GeneCards: HCN3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 155,277,463 bp [1] End 155,289,848 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 89,053,381 bp [2] End 89,067,503 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pituitary gland anterior pituitary hypothalamus superior frontal gyrus renal cortex skin of abdomen duodenum right adrenal gland stromal cell of endometrium Top expressed in entorhinal cortex pineal gland barrel cortex spinal ganglia olfactory bulb neural tube medulla oblongata mesencephalon primary motor cortex ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding potassium channel activity cAMP binding sodium channel activity voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity voltage-gated sodium channel activity protein binding Cellular component integral component of membrane membrane plasma membrane synapse neuronal cell body axon dendrite cone cell pedicle integral component of plasma membrane Biological process sodium ion transmembrane transport sodium ion transport cellular response to dopamine regulation of membrane potential regulation of ion transmembrane transport ion transport potassium ion transport response to cisplatin transmembrane transport potassium ion transmembrane transport cellular response to cAMP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57657 15168 Ensembl ENSG00000143630 ENSG00000263324 ENSMUSG00000028051 UniProt Q9P1Z3 O88705 RefSeq (mRNA) NM_020897 NM_008227 RefSeq (protein) NP_065948 NP_032253 Location (UCSC) Chr 1: 155.28 – 155.29 Mb Chr 3: 89.05 – 89.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene. ^{[5] [6]}

See also

• Cyclic nucleotide-gated ion channel

References

1. ENSG00000263324 GRCh38: Ensembl release 89: ENSG00000143630, ENSG00000263324 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028051 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID   16382102. S2CID   45853869.
6. "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

Further reading

• Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. Bibcode:1997PNAS...9414815S. doi: 10.1073/pnas.94.26.14815 . PMC   25120 . PMID   9405696.
• Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels". Nature. 393 (6685): 587–91. Bibcode:1998Natur.393..587L. doi:10.1038/31255. PMID   9634236. S2CID   4429453.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi: 10.1074/jbc.M306958200 . PMID   12928435.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stieber J, Stöckl G, Herrmann S, et al. (2005). "Functional expression of the human HCN3 channel". J. Biol. Chem. 280 (41): 34635–43. doi: 10.1074/jbc.M502508200 . PMID   16043489.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

External links

• HCN3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.