KCNA6

KCNA6
Identifiers
Aliases	KCNA6 , HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6
External IDs	OMIM: 176257 MGI: 96663 HomoloGene: 1684 GeneCards: KCNA6
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.32 Start 4,809,334 bp [1] End 4,813,318 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F3|6 61.72 cM Start 126,685,292 bp [2] End 126,717,637 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex islet of Langerhans Brodmann area 9 Achilles tendon cingulate gyrus ganglionic eminence hypothalamus caudate nucleus superior frontal gyrus Brodmann area 46 Top expressed in medial dorsal nucleus superior frontal gyrus lateral hypothalamus globus pallidus medial vestibular nucleus trigeminal ganglion cerebellar cortex lateral geniculate nucleus medial geniculate nucleus ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity Cellular component axon terminus integral component of membrane voltage-gated potassium channel complex axon plasma membrane potassium channel complex integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3742 16494 Ensembl ENSG00000151079 ENSMUSG00000038077 UniProt P17658 Q61923 RefSeq (mRNA) NM_002235 NM_013568 RefSeq (protein) NP_002226 NP_038596 Location (UCSC) Chr 12: 4.81 – 4.81 Mb Chr 6: 126.69 – 126.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene. ^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

1. GRCh38: Ensembl release 89: ENSG00000151079 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038077 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels" (PDF). Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels. 3 (3): 213–20. PMID   8821794.
• Tan KM, Lennon VA, Klein CJ, et al. (2008). "Clinical spectrum of voltage-gated potassium channel autoimmunity". Neurology. 70 (20): 1883–90. doi:10.1212/01.wnl.0000312275.04260.a0. PMID   18474843. S2CID   34815377.
• Grupe A, Schröter KH, Ruppersberg JP, et al. (1990). "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family". EMBO J. 9 (6): 1749–56. doi:10.1002/j.1460-2075.1990.tb08299.x. PMC   551878 . PMID   2347305.
• Yusifov T, Savalli N, Gandhi CS, et al. (2008). "The RCK2 domain of the human BKCa channel is a calcium sensor". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 376–81. Bibcode:2008PNAS..105..376Y. doi: 10.1073/pnas.0705261105 . PMC   2224220 . PMID   18162557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Kv1.6+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNA6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)