KCNA5

KCNA5
Identifiers
Aliases	KCNA5 , ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1, potassium voltage-gated channel subfamily A member 5
External IDs	OMIM: 176267 MGI: 96662 HomoloGene: 1683 GeneCards: KCNA5
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.32 Start 5,043,879 bp [1] End 5,046,788 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F3|6 61.35 cM Start 126,509,514 bp [2] End 126,512,375 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery popliteal artery ascending aorta left coronary artery gastric mucosa saphenous vein endothelial cell vena cava islet of Langerhans nucleus accumbens Top expressed in olfactory epithelium trigeminal nerve retina endocardial cushion olfactory tubercle renal pelvis nucleus accumbens myocardium of ventricle cardiac muscles arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel inhibitor activity outward rectifier potassium channel activity potassium channel activity scaffold protein binding voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in SA node cell action potential repolarization delayed rectifier potassium channel activity voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization voltage-gated ion channel activity ion channel activity protein binding alpha-actinin binding voltage-gated potassium channel activity signaling receptor binding protein kinase binding Cellular component integral component of membrane Golgi apparatus membrane intercalated disc intracellular canaliculus voltage-gated potassium channel complex plasma membrane integral component of plasma membrane potassium channel complex Z disc endoplasmic reticulum perinuclear region of cytoplasm caveola membrane raft cell surface Biological process Notch signaling pathway regulation of atrial cardiac muscle cell membrane repolarization positive regulation of myoblast proliferation regulation of potassium ion transport response to hypoxia membrane hyperpolarization regulation of insulin secretion response to hyperoxia regulation of membrane potential regulation of ion transmembrane transport response to mechanical stimulus ion transport response to organic substance membrane repolarization during bundle of His cell action potential positive regulation of G1/S transition of mitotic cell cycle potassium ion transport regulation of vasoconstriction potassium ion homeostasis protein complex oligomerization transmembrane transport potassium ion transmembrane transport negative regulation of potassium ion transport atrial cardiac muscle cell action potential membrane repolarization during SA node cell action potential regulation of heart rate by cardiac conduction protein homooligomerization response to hydrogen peroxide negative regulation of cytosolic calcium ion concentration membrane repolarization during atrial cardiac muscle cell action potential regulation of molecular function transport potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3741 16493 Ensembl ENSG00000130037 ENSMUSG00000045534 UniProt P22460 Q61762 RefSeq (mRNA) NM_002234 NM_145983 RefSeq (protein) NP_002225 NP_666095 Location (UCSC) Chr 12: 5.04 – 5.05 Mb Chr 6: 126.51 – 126.51 Mb PubMed search [3] [4]
Wikidata
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Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a protein that in humans is encoded by the KCNA5 gene. ^[5]

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. ^[5] Mutations in this gene have been related to both atrial fibrillation ^[6] and sudden cardiac death. ^[7] KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions

KCNA5 has been shown to interact with DLG4, ^{[8] [9]} PDZ domain-containing proteins such as SAP97, ^[10] and Actinin, alpha 2. ^{[8] [11]}

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000130037 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045534 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5".
6. Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A (Jul 2006). "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation". Human Molecular Genetics. 15 (14): 2185–91. doi:10.1093/hmg/ddl143. PMID   16772329.
7. Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP (Mar 2007). "Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients". Biochemical and Biophysical Research Communications. 354 (3): 776–82. doi:10.1016/j.bbrc.2007.01.048. PMID   17266934.
8. Eldstrom J, Choi WS, Steele DF, Fedida D (Jul 2003). "SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism". FEBS Letters. 547 (1–3): 205–11. doi:10.1016/S0014-5793(03)00668-9. PMID   12860415. S2CID   34857270.
9. Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters. 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID   12435606. S2CID   40689829.
10. Murata, Mitsunobu; Buckett, Peter D.; Zhou, Jun; Brunner, Michael; Folco, Eduardo; Koren, Gideon (2001-12-01). "SAP97 interacts with Kv1.5 in heterologous expression systems". American Journal of Physiology. Heart and Circulatory Physiology. 281 (6): H2575–H2584. doi: 10.1152/ajpheart.2001.281.6.H2575 . ISSN   0363-6135. PMID   11709425. S2CID   28915450.
11. Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters. 473 (2): 188–94. doi: 10.1016/S0014-5793(00)01521-0 . PMID   10812072. S2CID   13026110.

Further reading

• Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
• Curran ME, Landes GM, Keating MT (Apr 1992). "Molecular cloning, characterization, and genomic localization of a human potassium channel gene". Genomics. 12 (4): 729–37. doi:10.1016/0888-7543(92)90302-9. PMID   1349297.
• Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF (Jan 1991). "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel". Proceedings of the National Academy of Sciences of the United States of America. 88 (1): 53–7. Bibcode:1991PNAS...88...53P. doi: 10.1073/pnas.88.1.53 . PMC   50746 . PMID   1986382.
• Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM (Mar 1991). "Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle". FASEB Journal. 5 (3): 331–7. doi: 10.1096/fasebj.5.3.2001794 . PMID   2001794. S2CID   23737559.
• Mays DJ, Foose JM, Philipson LH, Tamkun MM (Jul 1995). "Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue". The Journal of Clinical Investigation. 96 (1): 282–92. doi:10.1172/JCI118032. PMC   185199 . PMID   7615797.
• Crumb WJ, Wible B, Arnold DJ, Payne JP, Brown AM (Jan 1995). "Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity". Molecular Pharmacology. 47 (1): 181–90. PMID   7838127.
• Phromchotikul T, Browne DL, Curran ME, Keating MT, Litt M (Sep 1993). "Dinucleotide repeat polymorphism at the KCNA5 locus". Human Molecular Genetics. 2 (9): 1512. doi:10.1093/hmg/2.9.1512-a. PMID   8242092.
• Albrecht B, Weber K, Pongs O (1996). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Receptors & Channels. 3 (3): 213–20. PMID   8821794.
• Holmes TC, Fadool DA, Ren R, Levitan IB (Dec 1996). "Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain". Science. 274 (5295): 2089–91. Bibcode:1996Sci...274.2089H. doi:10.1126/science.274.5295.2089. PMID   8953041.
• Lacerda AE, Roy ML, Lewis EW, Rampe D (Aug 1997). "Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart". Molecular Pharmacology. 52 (2): 314–22. doi:10.1124/mol.52.2.314. PMID   9271355.
• Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (Oct 1998). "Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density". Circulation. 98 (14): 1383–93. doi: 10.1161/01.cir.98.14.1383 . PMID   9760292.
• Maruoka ND, Steele DF, Au BP, Dan P, Zhang X, Moore ED, Fedida D (May 2000). "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells". FEBS Letters. 473 (2): 188–94. doi: 10.1016/S0014-5793(00)01521-0 . PMID   10812072. S2CID   13026110.
• Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A (Aug 2000). "Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon". The EMBO Journal. 19 (15): 4036–45. doi:10.1093/emboj/19.15.4036. PMC   306594 . PMID   10921884.
• Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC (Jan 2001). "A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 705–10. doi: 10.1073/pnas.031446198 . PMC   14652 . PMID   11149959.
• Cukovic D, Lu GW, Wible B, Steele DF, Fedida D (Jun 2001). "A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2". FEBS Letters. 498 (1): 87–92. doi: 10.1016/S0014-5793(01)02505-4 . PMID   11389904. S2CID   20622483.
• Kurata HT, Soon GS, Eldstrom JR, Lu GW, Steele DF, Fedida D (Aug 2002). "Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels". The Journal of Biological Chemistry. 277 (32): 29045–53. doi: 10.1074/jbc.M111470200 . PMID   12021261.
• Williams CP, Hu N, Shen W, Mashburn AB, Murray KT (Aug 2002). "Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit". The Journal of Pharmacology and Experimental Therapeutics. 302 (2): 545–50. doi:10.1124/jpet.102.033357. PMID   12130714. S2CID   34085749.
• Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters. 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID   12435606. S2CID   40689829.
• Zhang S, Kurata HT, Kehl SJ, Fedida D (Mar 2003). "Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition". The Journal of General Physiology. 121 (3): 215–25. doi:10.1085/jgp.20028760. PMC   2217332 . PMID   12601085.

External links

• Kv1.5+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNA5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.