CNGA1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CNGA1 , CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123825; MGI: 88436; HomoloGene: 55432; GeneCards: CNGA1; OMA:CNGA1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. [5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium. [6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio. [7] [8] [9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current. [10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.