Cyclic nucleotide-gated channel alpha 1

Last updated

CNGA1
Identifiers
Aliases CNGA1 , CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1
External IDs OMIM: 123825; MGI: 88436; HomoloGene: 55432; GeneCards: CNGA1; OMA:CNGA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000087
NM_001142564
NM_001379270

NM_007723

RefSeq (protein)

NP_000078
NP_001136036
NP_001366199
NP_000078.2

NP_031749

Location (UCSC) Chr 4: 47.94 – 48.02 Mb Chr 5: 72.76 – 72.8 Mb
PubMed search [3] [4]
Wikidata
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Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. [5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium. [6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio. [7] [8] [9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current. [10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

Contents

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198515 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067220 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Ncbi.nlm.nih.gov. Retrieved 2016-08-02.
  6. Kaupp UB, Niidome T, Tanabe T, Terada S, Bonigk W, Stuhmer W, et al. (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature. 342 (6251): 762–766. Bibcode:1989Natur.342..762K. doi:10.1038/342762a0. hdl: 11858/00-001M-0000-002B-B7A4-3 . ISSN   0028-0836. PMID   2481236. S2CID   4254661.
  7. Zheng J, Trudeau MC, Zagotta WN (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron. 36 (5): 891–896. doi: 10.1016/s0896-6273(02)01099-1 . ISSN   0896-6273. PMID   12467592. S2CID   15365006.
  8. Zhong H, Molday LL, Molday RS, Yau KW (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature. 420 (6912): 193–198. Bibcode:2002Natur.420..193Z. doi:10.1038/nature01201. ISSN   0028-0836. PMC   2877395 . PMID   12432397.
  9. Weitz D, Ficek N, Kremmer E, Bauer PJ, Kaupp UB (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron. 36 (5): 881–889. doi: 10.1016/s0896-6273(02)01098-x . ISSN   0896-6273. PMID   12467591. S2CID   17176092.
  10. Chen TY, Peng YW, Dhallan RS, Ahamed B, Reed RR, Yau KW (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature. 362 (6422): 764–767. Bibcode:1993Natur.362..764C. doi:10.1038/362764a0. ISSN   0028-0836. PMID   7682292. S2CID   4350775.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.