KCNS3

Last updated
KCNS3
Identifiers
Aliases KCNS3 , KV9.3, potassium voltage-gated channel modifier subfamily S member 3
External IDs OMIM: 603888 MGI: 1098804 HomoloGene: 20518 GeneCards: KCNS3
Orthologs
SpeciesHumanMouse
Entrez

3790

238076

Ensembl

ENSG00000170745

ENSMUSG00000043673

UniProt

Q9BQ31

Q8BQZ8

RefSeq (mRNA)

NM_001282428
NM_002252

NM_001168564
NM_173417

RefSeq (protein)

NP_001269357
NP_002243

NP_001162036
NP_775593

Location (UCSC) Chr 2: 17.88 – 18.36 Mb Chr 12: 11.14 – 11.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene. [5] [6] [7] KCNS3 gene belongs to the S subfamily of the potassium channel family. [7] It is highly expressed in pulmonary artery myocytes, [8] [9] [10] placenta, [11] and parvalbumin-containing GABA neurons in brain cortex. [12] [13] In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness, [14] whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia. [13]

Contents

Function

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The Kv9.3 protein (encoded by KCNS3 gene) is not functional by itself [9] but can form functional heteromultimers with Kv2.1 (encoded by KCNB1) and Kv2.2 (encoded by KCNB2) (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. [8] Heteromeric Kv2.1/Kv9.3 channels form with fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit. [15]

See also

Related Research Articles

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Kv7.1 (KvLQT1) is a potassium channel protein whose primary subunit in humans is encoded by the KCNQ1 gene. Kv7.1 is a voltage and lipid-gated potassium channel present in the cell membranes of cardiac tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction. It is a member of the KCNQ family of potassium channels.

<span class="mw-page-title-main">KCND2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCNA2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCNB1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCND3</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

<span class="mw-page-title-main">KCNAB1</span> Protein-coding gene in the species Homo sapiens

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.

<span class="mw-page-title-main">KCNAB2</span> Protein-coding gene in the species Homo sapiens

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.

<span class="mw-page-title-main">KCNC4</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCNH5</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel, subfamily H (eag-related), member 5, also known as KCNH5, is a human gene encoding the Kv10.2 protein.

<span class="mw-page-title-main">KCNJ9</span> Protein-coding gene in the species Homo sapiens

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

<span class="mw-page-title-main">KCNC1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCNC3</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or Kv3.3 is a protein that in humans is encoded by the KCNC3.

<span class="mw-page-title-main">KCNA10</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">KCNB2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNF1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the KCNF1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNG2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 2 is a protein that in humans is encoded by the KCNG2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNG4</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNV1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNS1</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

<span class="mw-page-title-main">KCNS2</span> Protein-coding gene in the species Homo sapiens

Potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170745 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043673 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3): C412–C424. doi:10.1152/ajpcell.1999.277.3.C412. PMID   10484328.
  6. ↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
  7. 1 2 "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3" . Retrieved 19 June 2017.
  8. 1 2 Patel AJ, Lazdunski M, Honoré E (November 1997). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". The EMBO Journal. 16 (22): 6615–6625. doi:10.1093/emboj/16.22.6615. PMC   1170266 . PMID   9362476.
  9. 1 2 Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–934. doi:10.1006/bbrc.1998.9072. PMID   9704029.
  10. ↑ Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, et al. (November 2006). "Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L993-1004. doi:10.1152/ajplung.00191.2005. PMID   16815889.
  11. ↑ Fyfe GK, Panicker S, Jones RL, Wareing M (October 2012). "Expression of an electrically silent voltage-gated potassium channel in the human placenta". Journal of Obstetrics and Gynaecology. 32 (7): 624–629. doi:10.3109/01443615.2012.709288. PMID   22943705. S2CID   27217929.
  12. ↑ Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T (2012). "Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex". PLOS ONE. 7 (8): e43904. Bibcode:2012PLoSO...743904G. doi: 10.1371/journal.pone.0043904 . PMC   3427167 . PMID   22937123.
  13. 1 2 Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, et al. (January 2014). "Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia". The American Journal of Psychiatry. 171 (1): 62–71. doi:10.1176/appi.ajp.2013.13040468. PMC   3947279 . PMID   24170294.
  14. ↑ Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–383. doi:10.1007/s00439-005-1256-5. PMID   15714333. S2CID   20997775.
  15. ↑ Kerschensteiner D, Soto F, Stocker M (April 2005). "Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6160–6165. Bibcode:2005PNAS..102.6160K. doi: 10.1073/pnas.0500468102 . PMC   1087924 . PMID   15827117.

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