KCNIP2

KCNIP2
Identifiers
Aliases	KCNIP2 , KCHIP2, potassium voltage-gated channel interacting protein 2
External IDs	OMIM: 604661; MGI: 2135916; HomoloGene: 23710; GeneCards: KCNIP2; OMA:KCNIP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 101,825,974 bp [1] End 101,843,920 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 38.75 cM Start 45,780,278 bp [2] End 45,804,500 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right auricle of heart nucleus accumbens caudate nucleus putamen right frontal lobe left ventricle anterior cingulate cortex cardiac muscle tissue of right atrium right hemisphere of cerebellum Top expressed in interventricular septum olfactory tubercle dentate gyrus lateral septal nucleus superior frontal gyrus dentate gyrus of hippocampal formation granule cell nucleus accumbens primary visual cortex anterior amygdaloid area myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding potassium channel activity ER retention sequence binding transmembrane transporter binding protein N-terminus binding metal ion binding voltage-gated ion channel activity protein binding A-type (transient outward) potassium channel activity identical protein binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization potassium channel regulator activity Cellular component cytoplasm membrane plasma membrane potassium channel complex voltage-gated potassium channel complex Biological process clustering of voltage-gated potassium channels muscle contraction regulation of heart contraction regulation of ion transmembrane transport ion transport detection of calcium ion potassium ion transport membrane repolarization regulation of cation channel activity potassium ion transmembrane transport regulation of potassium ion transmembrane transport signal transduction chemical synaptic transmission membrane repolarization during cardiac muscle cell action potential potassium ion export across plasma membrane positive regulation of potassium ion export across plasma membrane positive regulation of voltage-gated potassium channel activity cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30819 80906 Ensembl ENSG00000120049 ENSMUSG00000025221 UniProt Q9NS61 Q9JJ69 RefSeq (mRNA) NM_014591 NM_173191 NM_173192 NM_173193 NM_173194 NM_173195 NM_173197 NM_173342 NM_001276358 NM_030716 NM_145703 NM_145704 RefSeq (protein) NP_055406 NP_775283 NP_775284 NP_775285 NP_775286 NP_775287 NP_775289 NP_001263287 NP_109641 NP_663749 NP_663750 Location (UCSC) Chr 10: 101.83 – 101.84 Mb Chr 19: 45.78 – 45.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

K_v channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene. ^{[5] [6]}

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. ^[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms. ^[6]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000120049 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025221 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID   10676964. S2CID   4419472.
6. "Entrez Gene: KCNIP2 Kv channel interacting protein 2".
7. Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–93. doi:10.1038/nrn2093. PMC   1887812 . PMID   17311005.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y (Mar 2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochemical and Biophysical Research Communications. 282 (1): 96–102. doi:10.1006/bbrc.2001.4558. PMID   11263977.
• Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D (Jun 2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". The Journal of Biological Chemistry. 276 (26): 23888–94. doi: 10.1074/jbc.M101320200 . PMID   11287421.
• Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D (May 2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle". The Journal of Physiology. 533 (Pt 1): 119–25. doi:10.1111/j.1469-7793.2001.0119b.x. PMC   2278594 . PMID   11351020.
• Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K, Wollnik B (Nov 2001). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant". Cardiovascular Research. 52 (2): 255–64. doi: 10.1016/S0008-6363(01)00374-1 . PMID   11684073.
• Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR (Dec 2001). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia". Cell. 107 (6): 801–13. doi: 10.1016/S0092-8674(01)00588-8 . PMID   11747815. S2CID   18389247.
• Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF (Jul 2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation. 106 (4): 423–9. doi: 10.1161/01.CIR.0000025417.65658.B6 . PMID   12135940.
• Deschênes I, Tomaselli GF (Sep 2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Letters. 528 (1–3): 183–8. doi: 10.1016/S0014-5793(02)03296-9 . PMID   12297301. S2CID   41910930.
• Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS (Sep 2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". The Journal of Biological Chemistry. 278 (38): 36445–54. doi: 10.1074/jbc.M306142200 . PMID   12829703.
• Ren X, Shand SH, Takimoto K (Oct 2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". The Journal of Biological Chemistry. 278 (44): 43564–70. doi: 10.1074/jbc.M302337200 . PMID   12928444.
• Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA (Feb 2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2". The Journal of Biological Chemistry. 279 (7): 5549–54. doi: 10.1074/jbc.M311332200 . PMID   14623880.
• Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N (Feb 2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution". Neuron. 41 (4): 513–9. doi: 10.1016/S0896-6273(04)00050-9 . PMID   14980201. S2CID   18151379.
• Lin YL, Lin SR, Wu TT, Chang LS (Jul 2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochemical and Biophysical Research Communications. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID   15184042.
• Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS (Sep 2004). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain". The Journal of Neuroscience. 24 (36): 7903–15. doi: 10.1523/JNEUROSCI.0776-04.2004 . PMC   6729940 . PMID   15356203.
• Lin YL, Chen CY, Cheng CP, Chang LS (Aug 2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochemical and Biophysical Research Communications. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID   15358149.

External links

• KCNIP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.