KCNF1

KCNF1
Identifiers
Aliases	KCNF1 , IK8, KCNF, KV5.1, kH1, potassium voltage-gated channel modifier subfamily F member 1
External IDs	OMIM: 603787 MGI: 2687399 HomoloGene: 124236 GeneCards: KCNF1
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.1 Start 10,911,934 bp [1] End 10,914,225 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A1.1 Start 17,222,101 bp [2] End 17,226,889 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex putamen nucleus accumbens caudate nucleus cingulate gyrus dorsolateral prefrontal cortex Brodmann area 9 orbitofrontal cortex Brodmann area 10 superior frontal gyrus Top expressed in temporal lobe prefrontal cortex amygdala piriform cortex olfactory bulb superior frontal gyrus supraoptic nucleus nucleus accumbens primary motor cortex cingulate gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3754 382571 Ensembl ENSG00000162975 ENSMUSG00000051726 UniProt Q9H3M0 Q7TSH7 RefSeq (mRNA) NM_002236 NM_201531 RefSeq (protein) NP_002227 NP_963289 Location (UCSC) Chr 2: 10.91 – 10.91 Mb Chr 12: 17.22 – 17.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the KCNF1 gene. ^{[5] [6]} The protein encoded by this gene is a voltage-gated potassium channel subunit. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051726 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun. 241 (3): 675–81. doi:10.1006/bbrc.1997.7830. PMID   9434767.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. Bibcode:2002PNAS...99.7986O. doi: 10.1073/pnas.122617999 . PMC   123007 . PMID   12060745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Kv3.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)