CLCA1

CLCA1
Identifiers
Aliases	CLCA1 , CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1
External IDs	OMIM: 603906; MGI: 1346342; HomoloGene: 984; GeneCards: CLCA1; OMA:CLCA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p22.3 Start 86,468,368 bp [1] End 86,500,259 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 H2|3 69.26 cM Start 144,709,578 bp [2] End 144,738,537 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon jejunal mucosa mucosa of transverse colon rectum duodenum cecum appendix pancreatic ductal cell epithelium of colon Top expressed in left colon intestinal villus cervix pyloric antrum ileum duodenum mucous cell of stomach crypt of lieberkuhn of small intestine epithelium of small intestine jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding peptidase activity hydrolase activity chloride channel activity metallopeptidase activity metalloendopeptidase activity intracellular calcium activated chloride channel activity Cellular component extracellular region integral component of membrane integral component of plasma membrane microvillus zymogen granule membrane membrane plasma membrane secretory granule extracellular space Biological process calcium ion transport proteolysis chloride transport ion transport ion transmembrane transport cellular response to hypoxia chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1179 23844 Ensembl ENSG00000016490 ENSMUSG00000028255 UniProt A8K7I4 Q9D7Z6 RefSeq (mRNA) NM_001285 NM_017474 RefSeq (protein) NP_001276 NP_059502 Location (UCSC) Chr 1: 86.47 – 86.5 Mb Chr 3: 144.71 – 144.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene. ^{[5] [6]}

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. ^[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease. ^[7]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000016490 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028255 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. 54 (2): 200–14. doi: 10.1006/geno.1998.5562 . PMID   9828122.
6. "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
7. Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID   16470849. S2CID   40041491.

Further reading

• Hume JR, Duan D, Collier ML, et al. (2000). "Anion transport in heart". Physiol. Rev. 80 (1): 31–81. doi: 10.1152/physrev.2000.80.1.31 . PMID   10617765. S2CID   15954128.
• Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID   11071307. S2CID   28762005.
• Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi: 10.1016/S0014-5793(99)00891-1 . PMID   10437792. S2CID   82094058.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi: 10.1073/pnas.090521697 . PMC   18318 . PMID   10758170.
• Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. doi: 10.1067/mai.2002.121555 . PMID   11842292.
• Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. doi: 10.1074/jbc.C200215200 . PMID   11994272.
• Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. doi: 10.1074/jbc.M205307200 . PMID   12110680.
• Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. doi:10.1016/S0006-291X(02)02498-1. PMID   12408984.
• Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–65, discussion 165–70, 277–82. doi:10.1002/0470860790.ch10. ISBN   9780470844786. PMID   12568493.
• Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. doi: 10.1074/jbc.M309086200 . PMID   14512419.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hegab AE, Sakamoto T, Uchida Y, et al. (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. 41 (3): 27e–27. doi:10.1136/jmg.2003.012484. PMC   1735703 . PMID   14985398.
• Kamada F, Suzuki Y, Shao C, et al. (2005). "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. 5 (7): 540–7. doi: 10.1038/sj.gene.6364124 . PMID   15318163.
• Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID   15490240. S2CID   12935280.
• Gibson A, Lewis AP, Affleck K, et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. doi: 10.1074/jbc.M504654200 . PMID   15919655.
• Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca²⁺-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID   16023076.

External links

• CLCA1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCA1 genome location and CLCA1 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.