KCNK10

Last updated
KCNK10
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases KCNK10 , K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDs OMIM: 605873 MGI: 1919508 HomoloGene: 11321 GeneCards: KCNK10
Gene location (Human)
Ideogram human chromosome 14.svg
Chr. Chromosome 14 (human) [1]
Human chromosome 14 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 14q31.3Start88,180,103 bp [1]
End88,326,907 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021161
NM_138317
NM_138318

NM_029911
NM_001316664
NM_001316665
NM_001316666

RefSeq (protein)

NP_066984
NP_612190
NP_612191

n/a

Location (UCSC) Chr 14: 88.18 – 88.33 Mb Chr 12: 98.43 – 98.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains. [5] [6] [7]

Contents

See also

Related Research Articles

The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including signaling lipids, oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

KCNK2 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 2 is a protein that in humans is encoded by the KCNK2 gene.

KCNK3 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.

PHF10 protein-coding gene in the species Homo sapiens

PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.

KCNK1 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.

KCNK9 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.

KCNK4 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene.

Nucleoporin 133 protein-coding gene in the species Homo sapiens

Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.

KCNK6 Protein-coding gene in humans

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.

KCNK5 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.

KCNJ9 protein-coding gene in the species Homo sapiens

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

KCNJ13 protein-coding gene in the species Homo sapiens

Potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13) is a human gene encoding the Kir7.1 protein.

KCNK15 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene.

KCNK17 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.

KCNK7 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains. Multiple transcript variants encoding different isoforms have been found for this gene.

KCNK12 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.

KCNK13 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains.

KCNK16 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene. The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.

KCNK18 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100433 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033854 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi: 10.1074/jbc.M002822200 . PMID   10880510.
  6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106.
  7. Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. doi:10.1126/science.1261512. PMC   6034649 . PMID   25766236.

Further reading