KCNK10

Last updated
KCNK10
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases KCNK10 , K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDs OMIM: 605873 MGI: 1919508 HomoloGene: 11321 GeneCards: KCNK10
Gene location (Human)
Ideogram human chromosome 14.svg
Chr. Chromosome 14 (human) [1]
Human chromosome 14 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 14q31.3Start88,180,103 bp [1]
End88,326,907 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021161
NM_138317
NM_138318

NM_029911
NM_001316664
NM_001316665
NM_001316666

RefSeq (protein)

NP_066984
NP_612190
NP_612191

n/a

Location (UCSC) Chr 14: 88.18 – 88.33 Mb Chr 12: 98.43 – 98.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains. [5] [6] [7]

Contents

See also

Related Research Articles

The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including signaling lipids, oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

KCNK2 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 2 is a protein that in humans is encoded by the KCNK2 gene.

KCNK3 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.

PHF10 protein-coding gene in the species Homo sapiens

PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.

KCNK1 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.

KCNK9 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.

KCNK4 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene.

Nucleoporin 133 protein-coding gene in the species Homo sapiens

Nucleoporin 133 (Nup133) is a protein that in humans is encoded by the NUP133 gene.

KCNK6 Protein-coding gene in humans

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.

KCNK5 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.

KCNJ9 protein-coding gene in the species Homo sapiens

G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.

KCNJ13 protein-coding gene in the species Homo sapiens

Potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13) is a human gene encoding the Kir7.1 protein.

KCNK15 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene.

KCNK17 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.

KCNK7 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains. Multiple transcript variants encoding different isoforms have been found for this gene.

KCNK12 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.

KCNK13 protein-coding gene in the species Homo sapiens

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains.

KCNK16 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene. The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.

KCNK18 protein-coding gene in the species Homo sapiens

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100433 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033854 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi: 10.1074/jbc.M002822200 . PMID   10880510.
  6. ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106.
  7. ↑ Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. doi:10.1126/science.1261512. PMC   6034649 . PMID   25766236.

Further reading