CACNG4

CACNG4
Identifiers
Aliases	CACNG4 , calcium voltage-gated channel auxiliary subunit gamma 4
External IDs	OMIM: 606404 MGI: 1859167 HomoloGene: 8674 GeneCards: CACNG4
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q24.2 Start 66,964,707 bp [1] End 67,033,398 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E1 Start 107,623,183 bp [2] End 107,685,383 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence nucleus accumbens putamen caudate nucleus amygdala hypothalamus entorhinal cortex endothelial cell inferior olivary nucleus Brodmann area 46 Top expressed in otic placode saccule habenula nucleus accumbens ganglionic eminence olfactory bulb dorsomedial hypothalamic nucleus superior frontal gyrus superior cervical ganglion ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity channel regulator activity calcium channel activity voltage-gated calcium channel activity calcium channel regulator activity ionotropic glutamate receptor binding Cellular component endocytic vesicle membrane plasma membrane membrane voltage-gated calcium channel complex integral component of membrane integral component of plasma membrane AMPA glutamate receptor complex somatodendritic compartment cell surface postsynaptic density cell body postsynaptic density membrane L-type voltage-gated calcium channel complex glutamatergic synapse integral component of postsynaptic density membrane Biological process regulation of AMPA receptor activity regulation of ion transmembrane transport calcium ion transport ion transport transmission of nerve impulse membrane depolarization calcium ion transmembrane transport response to cocaine positive regulation of AMPA receptor activity regulation of postsynaptic neurotransmitter receptor activity positive regulation of synaptic transmission, glutamatergic neurotransmitter receptor transport, postsynaptic endosome to lysosome postsynaptic neurotransmitter receptor diffusion trapping neurotransmitter receptor internalization cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27092 54377 Ensembl ENSG00000075461 ENSMUSG00000020723 UniProt Q9UBN1 Q9JJV4 RefSeq (mRNA) NM_014405 NM_019431 RefSeq (protein) NP_055220 NP_062304 Location (UCSC) Chr 17: 66.96 – 67.03 Mb Chr 11: 107.62 – 107.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene. ^{[5] [6]}

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes. ^[6]

See also

• Voltage-dependent calcium channel

References

1. GRCh38: Ensembl release 89: ENSG00000075461 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020723 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Burgess DL, Davis CF, Gefrides LA, Noebels JL (Jan 2000). "Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication". Genome Res. 9 (12): 1204–13. doi:10.1101/gr.9.12.1204. PMC   311002 . PMID   10613843.
6. "Entrez Gene: CACNG4 calcium channel, voltage-dependent, gamma subunit 4".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Moss FJ, Dolphin AC, Clare JJ (2004). "Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes". BMC Neuroscience. 4: 23. doi: 10.1186/1471-2202-4-23 . PMC   270087 . PMID   14505496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chu PJ, Robertson HM, Best PM (2002). "Calcium channel gamma subunits provide insights into the evolution of this gene family". Gene. 280 (1–2): 37–48. doi:10.1016/S0378-1119(01)00738-7. PMID   11738816.
• Burgess DL, Gefrides LA, Foreman PJ, Noebels JL (2001). "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family". Genomics. 71 (3): 339–50. doi:10.1006/geno.2000.6440. PMID   11170751.
• Powers PA, Liu S, Hogan K, Gregg RG (1993). "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location". J. Biol. Chem. 268 (13): 9275–9. doi: 10.1016/S0021-9258(18)98346-8 . PMID   8387489.

External links

• CACNG4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CACNG4 genome location and CACNG4 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.