KCNV1

KCNV1
Identifiers
Aliases	KCNV1 , HNKA, KCNB3, KV2.3, KV8.1, potassium voltage-gated channel modifier subfamily V member 1
External IDs	OMIM: 608164 MGI: 1914748 HomoloGene: 22811 GeneCards: KCNV1
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q23.2 Start 109,963,636 bp [1] End 109,975,771 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B3.3 Start 44,969,680 bp [2] End 44,978,316 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex endothelial cell dorsolateral prefrontal cortex Brodmann area 9 superior frontal gyrus Brodmann area 23 Brodmann area 46 cingulate gyrus middle temporal gyrus orbitofrontal cortex Top expressed in prefrontal cortex primary motor cortex superior frontal gyrus piriform cortex temporal lobe hippocampus proper cingulate gyrus amygdala nucleus accumbens Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel inhibitor activity potassium channel regulator activity ion channel activity voltage-gated ion channel activity potassium channel activity voltage-gated potassium channel activity Cellular component plasma membrane membrane voltage-gated potassium channel complex integral component of membrane integral component of plasma membrane Biological process ion transport transmembrane transport potassium ion transport protein homooligomerization regulation of ion transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27012 67498 Ensembl ENSG00000164794 ENSMUSG00000022342 UniProt Q6PIU1 Q8BZN2 RefSeq (mRNA) NM_014379 NM_026200 RefSeq (protein) NP_055194 NP_080476 Location (UCSC) Chr 8: 109.96 – 109.98 Mb Chr 15: 44.97 – 44.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene. ^{[5] [6]} The protein encoded by this gene is a voltage-gated potassium channel subunit. ^{[5] [6]}

Common variations in the KCNV1 gene have been associated with schizophrenia. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164794 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022342 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M (Aug 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. doi:10.1002/j.1460-2075.1996.tb00697.x. PMC   451895 . PMID   8670833.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
7. Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014-07-24). "Biological insights from 108 schizophrenia-associated genetic loci". Nature. 511 (7510): 421–427. Bibcode:2014Natur.511..421S. doi:10.1038/nature13595. ISSN   1476-4687. PMC   4112379 . PMID   25056061.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sano A, Mikami M, Nakamura M, et al. (2002). "Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy". Epilepsia. 43 (Suppl 9): 26–31. doi: 10.1046/j.1528-1157.43.s.9.7.x . PMID   12383276. S2CID   39236204.
• Ebihara M, Ohba H, Kikuchi M, Yoshikawa T (2004). "Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene". Gene. 325: 89–96. doi:10.1016/j.gene.2003.09.044. PMID   14697513.
• Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". J. Biol. Chem. 272 (13): 8774–80. doi: 10.1074/jbc.272.13.8774 . PMID   9079713.

External links

• Kv8.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNV1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)