KCNH7

KCNH7
Identifiers
Aliases	KCNH7 , ERG3, HERG3, Kv11.3, potassium voltage-gated channel subfamily H member 7
External IDs	OMIM: 608169 MGI: 2159566 HomoloGene: 13249 GeneCards: KCNH7
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q24.2 Start 162,371,407 bp [1] End 162,838,767 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C1.3 Start 62,523,758 bp [2] End 63,014,631 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell ganglionic eminence tibialis anterior muscle islet of Langerhans prefrontal cortex blood corpus callosum deltoid muscle Brodmann area 46 spleen Top expressed in superior frontal gyrus granular layer primary motor cortex Purkinje cell internal granular layer spinal ganglia ganglionic eminence cingulate gyrus neural tube hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity potassium channel activity Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process ion transport transmembrane transport potassium ion transmembrane transport potassium ion transport regulation of membrane potential regulation of ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90134 170738 Ensembl ENSG00000184611 ENSMUSG00000059742 UniProt Q9NS40 Q9ER47 RefSeq (mRNA) NM_033272 NM_173162 NM_133207 RefSeq (protein) NP_150375 NP_775185 NP_573470 Location (UCSC) Chr 2: 162.37 – 162.84 Mb Chr 2: 62.52 – 63.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily H member 7 is a protein that in humans is encoded by the KCNH7 gene. ^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000184611 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059742 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Akhavan A, Atanasiu R, Noguchi T, et al. (2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". J. Cell Sci. 118 (Pt 13): 2803–12. doi: 10.1242/jcs.02423 . PMID   15961404.
• Ganetzky B, Robertson GA, Wilson GF, et al. (1999). "The eag family of K+ channels in Drosophila and mammals". Ann. N. Y. Acad. Sci. 868 (1): 356–69. Bibcode:1999NYASA.868..356G. doi:10.1111/j.1749-6632.1999.tb11297.x. PMID   10414305. S2CID   33512855.
• Martínez A, Santiago JL, Cénit MC, et al. (2008). "IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk". Eur. J. Hum. Genet. 16 (7): 861–4. doi: 10.1038/ejhg.2008.16 . PMID   18285833.
• Couturier N, Gourraud PA, Cournu-Rebeix I, et al. (2009). "IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients". Eur. J. Hum. Genet. 17 (6): 844–7. doi:10.1038/ejhg.2008.259. PMC   2947096 . PMID   19156166.
• Bauer CK, Wulfsen I, Schäfer R, et al. (2003). "HERG K(+) currents in human prolactin-secreting adenoma cells". Pflügers Arch. 445 (5): 589–600. doi:10.1007/s00424-002-0980-0. PMID   12634931. S2CID   20178757.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID   17474147. S2CID   22474278.

External links

• Kv11.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNH7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)