Aquaporin-5

AQP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5 , AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA:AQP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 49,961,872 bp [1] End 49,965,682 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.13 cM Start 99,488,663 bp [2] End 99,492,710 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa palpebral conjunctiva left testis right testis parotid gland skin of leg nasal epithelium minor salivary glands trachea skin of abdomen Top expressed in submandibular gland parotid gland lacrimal gland right lung right lung lobe respiratory epithelium olfactory epithelium trachea epithelium of lens left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding water channel activity identical protein binding channel activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane microvillus basal plasma membrane apical plasma membrane endoplasmic reticulum extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle Biological process excretion water transport pancreatic juice secretion saliva secretion odontogenesis ion transmembrane transport camera-type eye morphogenesis carbon dioxide transport transport transmembrane transport protein homotetramerization cellular hypotonic response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 362 11830 Ensembl ENSG00000161798 ENSMUSG00000044217 UniProt P55064 Q9WTY4 RefSeq (mRNA) NM_001651 NM_009701 RefSeq (protein) NP_001642 NP_033831 Location (UCSC) Chr 12: 49.96 – 49.97 Mb Chr 15: 99.49 – 99.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene. ^{[5] [6]}

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions. ^[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. ^[6]

AQP-5 features a homotetrameric structure embedded in the cell membrane with the center of each monomer acting as a water pore. ^[7] Each monomer structure is a transmembrane protein which have an asparagine–proline–alanine (NPA) hydrophobic residue embedded in the membrane of the cell. The NPA residue plays a role in water and solute permeability across the membrane of the cell. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000161798 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044217 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, et al. (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". Journal of Biological Chemistry. 271 (15): 8599–8604. doi: 10.1074/jbc.271.15.8599 . PMID   8621489.
6. "Entrez Gene: AQP5 aquaporin 5".
7. Direito I, Madeira A, Brito MA, Soveral G (Apr 2016). "Aquaporin-5: from structure to function and dysfunction in cancer". Cellular and Molecular Life Sciences. 73 (8): 1623–1640. doi:10.1007/s00018-016-2142-0. PMC   11108570 . PMID   26837927.

Further reading

• Verkman AS (Feb 2003). "Role of aquaporin water channels in eye function". Experimental Eye Research. 76 (2): 137–143. doi:10.1016/S0014-4835(02)00303-2. PMID   12565800.
• Ma T, Yang B, Umenishi F, Verkman AS (Aug 1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–389. doi:10.1006/geno.1997.4836. PMID   9268644.
• Smith JK, Siddiqui AA, Modica LA, Dykes R, Simmons C, Schmidt J, et al. (Aug 1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". Journal of Interferon & Cytokine Research. 19 (8): 929–935. doi:10.1089/107999099313479. PMID   10476940.
• Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC, Gabriel SE (Mar 2001). "Expression and localization of epithelial aquaporins in the adult human lung". American Journal of Respiratory Cell and Molecular Biology. 24 (3): 224–234. doi:10.1165/ajrcmb.24.3.4367. PMID   11245621. S2CID   12825671.
• Gresz V, Kwon TH, Hurley PT, Varga G, Zelles T, Nielsen S, et al. (Jul 2001). "Identification and localization of aquaporin water channels in human salivary glands". American Journal of Physiology. Gastrointestinal and Liver Physiology. 281 (1): G247 –G254. doi:10.1152/ajpgi.2001.281.1.G247. PMID   11408278.
• Nejsum LN, Kwon TH, Jensen UB, Fumagalli O, Frokiaer J, Krane CM, et al. (Jan 2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 511–516. Bibcode:2002PNAS...99..511N. doi: 10.1073/pnas.012588099 . PMC   117591 . PMID   11773623.
• Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, et al. (Jul 2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–1016. doi:10.1136/gut.52.7.1008. PMC   1773699 . PMID   12801959.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Chen Z, Wang X, Gao L, Bai L, Zhu R, Bai C (Apr 2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochemical and Biophysical Research Communications. 342 (3): 775–781. doi:10.1016/j.bbrc.2006.01.103. PMID   16500622.
• Sidhaye VK, Guler AD, Schweitzer KS, D'Alessio F, Caterina MJ, King LS (Mar 2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proceedings of the National Academy of Sciences of the United States of America. 103 (12): 4747–4752. Bibcode:2006PNAS..103.4747S. doi: 10.1073/pnas.0511211103 . PMC   1450241 . PMID   16537379.
• Pedersen PS, Braunstein TH, Jorgensen A, Larsen PL, Holstein-Rathlou NH, Frederiksen O (Mar 2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflugers Archiv: European Journal of Physiology. 453 (6): 777–785. doi:10.1007/s00424-006-0157-3. PMID   17043812. S2CID   6205954.
• Skowron-zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F (Jul 2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Experimental Cell Research. 313 (12): 2695–2702. doi:10.1016/j.yexcr.2007.02.035. PMID   17553491.

External links

• AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.