Parotid gland

Last updated
Parotid gland
Parotid gland en.png
Location of the left parotid gland in humans (shown in green).
SAG Parotid-Gland 191024 03.jpg
Image
Details
Part of Salivary glands
System Digestive system
Identifiers
Latin glandula parotidea
MeSH D010306
TA98 A05.1.02.003
TA2 2800
FMA 59790
Anatomical terminology

The parotid gland is a major salivary gland in many animals. In humans, the two parotid glands are present on either side of the mouth and in front of both ears. They are the largest of the salivary glands. Each parotid is wrapped around the mandibular ramus, and secretes serous saliva through the parotid duct into the mouth, to facilitate mastication and swallowing and to begin the digestion of starches. There are also two other types of salivary glands; they are submandibular and sublingual glands. [1] Sometimes accessory parotid glands are found close to the main parotid glands. [2]

Contents

Etymology

The word parotid literally means "beside the ear". From Greek παρωτίς (stem παρωτιδ-) : (gland) behind the ear < παρά - pará : in front, and οὖς - ous (stem ὠτ-, ōt-) : ear.

Structure

The parotid glands are a pair of mainly serous salivary glands located below and in front of each ear canal, draining their secretions into the vestibule of the mouth through the parotid duct. [3] Each gland lies behind the mandibular ramus and in front of the mastoid process of the temporal bone. The gland can be felt on either side, by feeling in front of each ear, along the cheek, and below the angle of the mandible. [4]

The parotid duct, a long excretory duct, emerges from the front of each gland, superficial to the masseter muscle. The duct pierces the buccinator muscle, then opens into the mouth on the inner surface of the cheek, usually opposite the maxillary second molar. The parotid papilla is a small elevation of tissue that marks the opening of the parotid duct on the inner surface of the cheek. [4]

The gland has four surfaces – superficial or lateral, superior, anteromedial, and posteromedial. The gland has three borders – anterior, medial, and posterior. The parotid gland has two ends – superior end in the form of small superior surface and an inferior end (apex).

A number of different structures pass through the gland. From lateral to medial, these are:

  1. Facial nerve
  2. Retromandibular vein
  3. External carotid artery
  4. Superficial temporal artery
  5. Branches of the great auricular nerve
  6. Maxillary artery

Sometimes accessory parotid glands are found as an anatomic variation. These are close to the main glands and consist of ectopic salivary gland tissue. [2]

Capsule of parotid gland

Capsule of the parotid gland is formed from the investing layer of the deep cervical fascia. It is supplied by great auricular nerve. The fascia splits to enclose the gland. This splitting occurs between the angle of the mandible and the mastoid process. The superficial lamina (parotidomassetric fascia) is thick and is attached to zygomatic arch. The deep lamina is thin and is attached to styloid process, tympanic plate and the ramus of the mandible. The part of deep lamina extending between the styloid process and the mandible is thickened to form stylomastoid ligament. The stylomandibular ligament separates parotid gland from the superficial lobe of the submandibular gland.[ citation needed ]

Relations

The facial nerve (CN VII) splits into its branches within the parotid gland, thus forming its parotid plexus. Nerves of this plexus then pass through the parotid gland without innervating the gland itself. [5]

Vasculature

Arterial supply

The external carotid artery and its terminal branches within the gland, namely, the superficial temporal and the maxillary artery, also the posterior auricular artery supply the parotid gland.[ citation needed ]

Venous drainage

Venous return is to the retromandibular veins.[ citation needed ]

Lymphatic drainage

The gland is mainly drained into the preauricular or parotid lymph nodes which ultimately drain to the deep cervical chain.[ citation needed ]

Nerve supply

The parotid gland receives both sensory and autonomic innervation.

Sympathetic

The cell bodies of the preganglionic sympathetic fibres that supply the gland usually lie in the lateral horns of upper thoracic spinal segments (T1-T3). [ citation needed ] Postganglionic sympathetic fibers from superior cervical ganglion reach the gland by passing along the external carotid artery and middle meningeal artery. They act to cause vasoconstriction. [6] : 359–360 

Parasympathetic

Preganglionic parasympathetic fibers for the parotid gland arise in the brainstem in the inferior salivatory nucleus, and leave the brain in the glossopharyngeal nerve (CN IX), then pass in the tympanic nerve to the tympanic plexus, then from the tympanic plexus in the lesser petrosal nerve to the otic ganglion where they synapse. Postganglionic (post-synaptic) fibers from the ganglion then "hitch-hike" along the auriculotemporal nerve to reach the parotid gland. [7] [8] : 255 

Sensory

General sensory innervation to the parotid gland and its capsule is provided by the auriculotemporal nerve. [9]

Histology

The parotid gland WVSOM Parotid Gland1.JPG
The parotid gland

The gland has a capsule of its own of dense connective tissue but is also provided with a false capsule by the investing layer of the deep cervical fascia. The fascia at the imaginary line between the angle of the mandible and the mastoid process splits into a superficial and a deep lamina to enclose the gland. The risorius is a small muscle embedded with this capsule substance.

The gland has short, striated ducts and long, intercalated ducts. [10] The intercalated ducts are also numerous and lined with cuboidal epithelial cells and have lumina larger than those of the acini. The striated ducts are also numerous and consist of simple columnar epithelium, having striations that represent the infolded basal cell membranes and mitochondria. [8] : 273 

Though the parotid gland is the largest, it provides only 25% of the total salivary volume. The serous cell predominates in the parotid, making the gland secrete a mainly serous secretory product. [10]

The parotid gland also secretes salivary alpha-amylase (sAA), which is the first step in the decomposition of starches during mastication. It is the main exocrine gland to secrete this. It breaks down amylose (straight chain starch) and amylopectin (branched starch) by hydrolyzing alpha 1,4 bonds. Additionally, the alpha amylase has been suggested to prevent bacterial attachment to oral surfaces and to enable bacterial clearance from the mouth. [11]

Development

The parotid salivary glands appear early in the sixth week of the prenatal development and are the first major salivary glands formed. The epithelial buds of these glands are located on the inner part of the cheek, near the labial commissures of the primitive mouth (from ectodermal lining near angles of the stomodeum in the 1st/2nd pharyngeal arches; the stomodeum itself is created from the rupturing of the oropharyngeal membrane at about 26 days. [12] ) These buds grow posteriorly toward the otic placodes of the ears and branch to form solid cords with rounded terminal ends near the developing facial nerve. Later, at around 10 weeks of prenatal development, these cords are canalized and form ducts, with the largest becoming the parotid duct for the parotid gland. The rounded terminal ends of the cords form the acini of the glands. Secretion by the parotid glands via the parotid duct begins at about 18 weeks of gestation. Again, the supporting connective tissue of the gland develops from the surrounding mesenchyme. [10]

Clinical significance

Parotitis

Inflammation of one or both parotid glands is known as parotitis. The most common cause of parotitis is mumps. Widespread vaccination against mumps has markedly reduced the incidence of mumps parotitis. The pain of mumps is due to the swelling of the gland within its fibrous capsule. [3]

Apart from viral infection, other infections, such as bacterial, can cause parotitis (acute suppurative parotitis or chronic parotitis). These infections may cause blockage of the duct by salivary duct calculi or external compression. Parotid gland swellings can also be due to benign lymphoepithelial lesions[ clarification needed ] caused by Mikulicz disease and Sjögren syndrome. Swelling of the parotid gland may also indicate the eating disorder bulimia nervosa, creating the look of a heavy jaw line. With the inflammation of mumps or obstruction of the ducts, increased levels of the salivary alpha amylase secreted by the parotid gland can be detected in the blood stream.

Mumps

Mumps is seen to be a common cause of parotid gland swelling –85% of cases occur in children younger than 15 years. The disease is highly contagious and spreads by airborne droplets from salivary, nasal, and urinary secretions. [13] Symptoms include oedema in the area, trismus as well as otalgia. The lesion tends to begin on one side of the face and eventually becomes bilateral. [13] The transmission of the paramyxovirus is by contact with the infected persons saliva. [13] Initial symptoms tend to be a headache and fever. Mumps is not fatal, however further complications can include swelling of the ovaries or the testes. [13] Diagnosis of mumps is confirmed through viral serology, management of the condition includes hydration and good oral hygiene of the patient [13] requiring excellent motivation. However, since the development of the mumps vaccine, given at the age of between 4–6 years, the incidence of this viral infection has greatly reduced. This vaccine has reduced the incidence by 99%. [13]

Fibrous reactions

Tuberculosis and syphilis can cause granuloma formation in the parotid glands.

Salivary stones

Salivary stones mainly occur within the main confluence of the ducts and within the main parotid duct. The patient usually complains of intense pain when salivating and tends to avoid foods which produce this symptom. In addition, the parotid gland may become enlarged upon trying to eat. The pain can be reproduced in clinic by squirting lemon juice into the mouth. Surgery depends upon the site of the stone: if within the anterior aspect of the duct, a simple incision into the buccal mucosa with sphinterotomy[ clarification needed ] may allow removal; however, if situated more posteriorly[ clarification needed ] within the main duct, complete gland excision may be necessary.

Injury

The parotid salivary gland can also be pierced and the facial nerve temporarily traumatized when an inferior alveolar local anesthesia nerve block is incorrectly administered, causing transient facial paralysis. [4]

Cancer and tumours

About 80% of tumors of the parotid gland are benign. [14] The most common of these include pleomorphic adenoma (70% of tumors, [14] of which 60% occur in females [14] ) and Warthin tumor (i.e. adenolymphoma, which is more common in males than in females). Their importance is in relation to their anatomical position and tendency to grow over time. The tumorous growth can also change the consistency of the gland and cause facial pain on the involved side. [4]

Around 20% of parotid tumors are malignant, with the most common tumors being mucoepidermoid carcinoma and adenoid cystic carcinoma. Other malignant tumors of the parotid gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma (arising from ductal epithelium of parotid gland), squamous cell carcinoma (arising from parenchyma of parotid gland), and undifferentiated carcinoma. Metastasis from other sites like phyllodes tumour of breast presenting as parotid swelling have also been described. [15] Critically, the relationship of the tumor to the branches of the facial nerve (CN VII) must be defined because resection may damage the nerves, resulting in paralysis of the muscles of facial expression.

Relative incidence of parotid tumors. Relative incidence of parotid tumors.png
Relative incidence of parotid tumors.

Benign

Neoplastic lesions of the parotid salivary gland can either be benign or malignant. Within the parotid gland, nearly 80% of tumours are benign. [17] Benign lesions tend to be painless, asymptomatic and slow-growing. The most common salivary gland neoplasms in children are hemangiomas, lymphatic malformations, and pleomorphic adenomas. [13] Diagnosis of benign lesions require a fine-needle-like aspiration biopsy. [13] With various benign lesions, most commonly the pleomorphic adenoma, there is a risk of developing malignancy over time. [13] As a result, these lesions are typically resected.

Pleomorphic adenoma is seen to be a common benign neoplasm of the salivary gland and has an overall incidence of 54–68%. [13] The Warthin tumour has a lower incidence of 6–10%; this tumour is associated with smoking and is more common in older men. [13] Benign lesions of the parotid gland have a significantly higher incidence than malignant lesions.

Malignant

Malignant salivary gland lesions are rare. However, when a tumour extends to the submandibular, sublingual and the minor salivary glands, they tend to be malignant. [13] Distinguishing a malignant lesion from a benign one may be difficult as they both present as painless lesions. [13] A biopsy is crucial in aiding diagnosis. There are common signs that can highlight the presence of a malignant lesion. These include facial nerve weakness, rapid increase of the size of the lump as well as ulceration of the mucosa of the skin. [13]

Mucoepidermoid carcinoma is a common malignant tumour of the salivary glands and has a low incidence of 4–13%. [13] Adenoid cystic carcinoma is also a common malignant salivary gland lesion and has an incidence of 4–8%. This carcinoma tends to invade nerves and can re-occur post-treatment. [13]

Polycystic parotid disease

A developmental polycystic disease of the salivary gland is seen to be extremely rare and is seen to be independent of recurrent parotitis. [18] The cause is thought to be a defect in the interactions between activin, follistatin and TGF-β, leading to a developmental disorder of glandular tissue. [18]

Surgery

Surgical treatment of parotid gland tumors is sometimes difficult because of the anatomical relations of the facial nerve parotid lodge, as well as the increased potential for postoperative relapse. Thus, detection of early stages of a parotid tumor is extremely important in terms of postoperative prognosis. [14] Operative technique is laborious, because of relapses and incomplete previous treatment made in other border specialties. [14] Surgical techniques in parotid surgery have evolved in the last years with the use of neuromonitoring of the facial nerve and have become safer and less invasive. [19]

After surgical removal of the parotid gland (parotidectomy), the auriculotemporal nerve is liable to damage and upon recovery it fuses with sweat glands. This can cause sweating on the cheek on the side of the face of the affected gland. This condition is known as Frey's syndrome. [20]

Infections

Bacterial infections

Acute bacterial parotitis

Commonly caused by a retrograde bacterial infection as a result of illness, sepsis, trauma, surgery, reduced salivary flow due to medications, diabetes, malnutrition and dehydration. Classically symptoms of painful swelling in the parotid region when eating seen. Management is based upon antibacterials, rehydration combined with gentle massage to encourage salivary flow. [21]

Chronic bacterial parotitis

A latent infection despite clinical resolution of the disease resulting in impaired function. Histologically glandular duct dilation, abscess formation and atrophy may be seen. Parotid secretions are viscous. Disease course shows pain and swelling, waxing and waning. Radiographic screening should be undertaken to rule out sialolith. Management with palliative care with parotidectomy as a last resort. [21]

Viral infections

Mumps

Acute non-suppurative disease that often occurs in epidemics. Prevented by MMR vaccine. Caused by paramyxovirus that is transmitted by infected saliva and urine. A prodromal period of 24–28 hours is experienced, followed by rapid and painful swelling of the parotid gland. Treatment is supportive (bedrest, hydration) as spontaneous resolution occurs within 5–10 days. [21]

HIV / AIDS

Diffuse gland enlargement is seen, and may affect patients throughout all stages of the infection. Lymphoepithelial cysts [22] seen via imaging help aid diagnosis. Pathogenic process occurs due to circulating CD8 lymphocytes within the salivary gland. Medical management via use of antiretrovirals, excellent oral hygiene measures and sialogogues. [21]

Systemic lupus erythematosus

Most commonly seen in fourth and fifth decades in women, and can affect any salivary gland. Presentation is a slowly enlarging gland, with diagnosis made by identification of the underlying systemic disorder and measurements of salivary chemical levels. Sodium and chloride ion levels will be elevated two or three times normal levels. Treatment is by addressing the underlying systemic condition. [21]

Sarcoidosis

Sarcoidosis is a chronic systemic disease characterised by the production of non-caseating granulomas of unknown aetiology. It can affect any organ of the body, depressing cellular immunity and enhancing humoral immunity.

Salivary gland involvement primarily involves both parotid glands, causing enlargement and swelling. Salivary gland biopsy with histopathologic examination is needed to make the distinction between whether Sjoren's syndrome or sarcoidosis is the cause of this. [21]

Sjogren's syndrome

Salivary gland enlargement occurs in up to 30% of patients with Sjogren's syndrome, with the parotid gland being most often enlarged, and bilateral parotid gland enlargement seen in 25–60% of patients. However, the parotid glands have a longer-lasting secretory capacity in Sjogren's syndrome patient and therefore are the last glands to manifest hyposalivation in the disease. Histopathology shows clustering of lymphocytic infiltrates and epimyoepithelial islands. [21]

Mycobacterial infection

The most common head and neck manifestation of tuberculosis mycobacterial disease is infection of cervical lymph nodes. The infection is thought to originate in the tonsils or gingiva, ascending to the parotid gland. Two clinical forms; acute and chronic lesions. Acute lesions have diffuse glandular edema, easily confused with acute sialdentitis or abscess. The chronic lesions occur as slow growing masses mimicking tumors. [21]

Examination of the salivary gland

History and examination

A patient with parotid swelling may complain of swelling, pain, xerostomia, bad taste and sometimes sialorrhoea. [23]

The most common presenting symptom of neoplasms (both benign and malignant) is an asymptomatic swelling. Pain is more common in patients with parotid cancer (10–29% feel pain) than those with benign neoplasms (only 2.5–4%), [23] but pain itself it not diagnostic of malignancy.

Episodic swelling of major salivary glands accompanied by pain and related to salivary stimuli suggests duct obstruction.

Also need to assess the facial nerve. The facial nerve passes through the parotid so may be affected if there is a change in the parotid gland. Facial nerve paralysis in a previously untreated patient usually indicates that a tumour is malignant. [23]

Physical examination

The superficial location of the salivary glands allows palpation and visual inspection. The inspection must be systematic, both intraorally and extraorally, so no area is missed.

For extraoral examination the patients head should be inclined forwards in order to maximally expose the parotid and submandibular glands. A normal parotid gland is barely palpable and a normal sublingual gland is not palpable. [23]

Intra-oral examination should include observations for asymmetry, discolouration, pulsation and obstructions in the duct orifices. Swelling of the deep lobe of the parotid gland may be seen intra-orally, and may also displace the tonsil. The minor salivary glands should be examined. The labial, buccal and posterior palatal mucosa should be dried with an air blower or tissue and pressed to assess the flow of saliva. [23]

Salivary testing

Salivary stimulation

Sialography

Sialochemistry

Radioisotope scintigraphy

Further tests

Additional images

See also

Related Research Articles

<span class="mw-page-title-main">Mumps</span> Human disease caused by paramyxovirus

Mumps is a highly contagious viral disease caused by the mumps virus. Initial symptoms of mumps are non-specific and include fever, headache, malaise, muscle pain, and loss of appetite. These symptoms are usually followed by painful swelling around the side of the face, which is the most common symptom of a mumps infection. Symptoms typically occur 16 to 18 days after exposure to the virus. About one third of people with a mumps infection do not have any symptoms (asymptomatic).

<span class="mw-page-title-main">Salivary gland</span> Exocrine glands that produce saliva through a system of ducts

The salivary glands in many vertebrates including mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands, as well as hundreds of minor salivary glands. Salivary glands can be classified as serous, mucous, or seromucous (mixed).

<span class="mw-page-title-main">Submandibular gland</span> Human salivary gland

The paired submandibular glands are major salivary glands located beneath the floor of the mouth. In adult humans, they each weigh about 15 grams and contribute some 60–67% of unstimulated saliva secretion; on stimulation their contribution decreases in proportion as parotid gland secretion rises to 50%. The average length of the normal adult human submandibular salivary gland is approximately 27 mm, while the average width is approximately 14.3 mm.

<span class="mw-page-title-main">Adenoid cystic carcinoma</span> Medical condition

Adenoid cystic carcinoma is a rare type of cancer that can exist in many different body sites. This tumor most often occurs in the salivary glands, but it can also be found in many anatomic sites, including the breast, lacrimal gland, lung, brain, Bartholin gland, trachea, and the paranasal sinuses.

<span class="mw-page-title-main">Parotitis</span> Medical condition

Parotitis is an inflammation of one or both parotid glands, the major salivary glands located on either side of the face, in humans. The parotid gland is the salivary gland most commonly affected by inflammation.

An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant.

<span class="mw-page-title-main">Parotid duct</span> Salivary duct from the parotid gland to the mouth

The parotid duct or Stensen duct is a salivary duct. It is the route that saliva takes from the major salivary gland, the parotid gland, into the mouth. It opens into the mouth opposite the second upper molar tooth.

The oral mucosa is the mucous membrane lining the inside of the mouth. It comprises stratified squamous epithelium, termed "oral epithelium", and an underlying connective tissue termed lamina propria. The oral cavity has sometimes been described as a mirror that reflects the health of the individual. Changes indicative of disease are seen as alterations in the oral mucosa lining the mouth, which can reveal systemic conditions, such as diabetes or vitamin deficiency, or the local effects of chronic tobacco or alcohol use. The oral mucosa tends to heal faster and with less scar formation compared to the skin. The underlying mechanism remains unknown, but research suggests that extracellular vesicles might be involved.

<span class="mw-page-title-main">Warthin's tumor</span> Medical condition

Warthin's tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers. It is named for pathologist Aldred Scott Warthin, who described two cases in 1929.

<span class="mw-page-title-main">Pleomorphic adenoma</span> Medical condition

Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. It is the most common type of salivary gland tumor and the most common tumor of the parotid gland. It derives its name from the architectural Pleomorphism seen by light microscopy. It is also known as "Mixed tumor, salivary gland type", which refers to its dual origin from epithelial and myoepithelial elements as opposed to its pleomorphic appearance.

<span class="mw-page-title-main">Benign lymphoepithelial lesion</span> Medical condition

Benign lymphoepithelial lesion or Mikulicz' disease is a type of benign enlargement of the parotid and/or lacrimal glands. This pathologic state is sometimes, but not always, associated with Sjögren's syndrome.

An oral medicine or stomatology doctor/dentist has received additional specialized training and experience in the diagnosis and management of oral mucosal abnormalities including oral cancer, salivary gland disorders, temporomandibular disorders and facial pain, taste and smell disorders; and recognition of the oral manifestations of systemic and infectious diseases. It lies at the interface between medicine and dentistry. An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region.

<span class="mw-page-title-main">Sialadenitis</span> Medical condition

Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common being the parotid gland, followed by submandibular and sublingual glands. It should not be confused with sialadenosis (sialosis) which is a non-inflammatory enlargement of the major salivary glands.

<span class="mw-page-title-main">Sialolithiasis</span> Medical condition

Sialolithiasis is a crystallopathy where a calcified mass or sialolith forms within a salivary gland, usually in the duct of the submandibular gland. Less commonly the parotid gland or rarely the sublingual gland or a minor salivary gland may develop salivary stones.

<span class="mw-page-title-main">Salivary gland tumour</span> Medical condition

Salivary gland tumours, also known as mucous gland adenomas or neoplasms, are tumours that form in the tissues of salivary glands. The salivary glands are classified as major or minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor salivary glands consist of 800 to 1000 small mucus-secreting glands located throughout the lining of the oral cavity. Patients with these types of tumours may be asymptomatic.

<span class="mw-page-title-main">Carcinoma ex pleomorphic adenoma</span> Medical condition

Carcinoma ex pleomorphic adenoma is a type of cancer typically found in the parotid gland. It arises from the benign tumour pleomorphic adenoma.

<span class="mw-page-title-main">Salivary gland disease</span> Medical condition

Salivary gland diseases (SGDs) are multiple and varied in cause. There are three paired major salivary glands in humans: the parotid glands, the submandibular glands, and the sublingual glands. There are also about 800–1,000 minor salivary glands in the mucosa of the mouth. The parotid glands are in front of the ears, one on side, and secrete mostly serous saliva, via the parotid ducts, into the mouth, usually opening roughly opposite the second upper molars. The submandibular gland is medial to the angle of the mandible, and it drains its mixture of serous and mucous saliva via the submandibular duct into the mouth, usually opening in a punctum in the floor of mouth. The sublingual gland is below the tongue, on the floor of the mouth; it drains its mostly mucous saliva into the mouth via about 8–20 ducts, which open along the plica sublingualis, a fold of tissue under the tongue.

<span class="mw-page-title-main">Parotidectomy</span> Surgical removal of the parotid gland

A parotidectomy is the surgical excision (removal) of the parotid gland, the major and largest of the salivary glands. The procedure is most typically performed due to neoplasms (tumors), which are growths of rapidly and abnormally dividing cells. Neoplasms can be benign (non-cancerous) or malignant (cancerous). The majority of parotid gland tumors are benign, however 20% of parotid tumors are found to be malignant. Parotidectomy is performed mostly by oral and maxillofacial surgeon and ENT surgeon.

Chronic sclerosing sialadenitis is a chronic (long-lasting) inflammatory condition affecting the salivary gland. Relatively rare in occurrence, this condition is benign, but presents as hard, indurated and enlarged masses that are clinically indistinguishable from salivary gland neoplasms or tumors. It is now regarded as a manifestation of IgG4-related disease.

<span class="mw-page-title-main">Sclerosing polycystic adenosis</span> Type of salivary gland tumor

Sclerosing polycystic adenosis is a rare salivary gland tumor first described in 1996 by Dr. Brion Smith. The major salivary glands, specifically the parotid gland and the submandibular gland, are affected most commonly. Patients usually come to clinical attention with a mass or swelling in their salivary glands in the 5th decade of life, with females affected much more commonly than males. Nearly all of the cases reported so far have a benign behavior, although there is a single case that has had an associated malignant transformation.

References

  1. ↑ "Submandibular Gland: Location, Function and Complications".
  2. 1 2 Ibrahim, Dalia. "Accessory parotid gland | Radiology Reference Article". Radiopaedia.
  3. 1 2 Jacobs S (2008). "Chapter 7: Head and Neck". Human Anatomy. Elsevier. p. 193. doi:10.1016/B978-0-443-10373-5.50010-5. ISBN   978-0-443-10373-5.
  4. 1 2 3 4 Fehrenbach MJ, Herring SW (2012). Illustrated anatomy of the head and neck (4th ed.). St. Louis, Mo.: Elsevier/Saunders. p. 154. ISBN   978-1-4377-2419-6.
  5. ↑ McGurk, Simon (2013-09-11). "Moore: Clinically Oriented Anatomy – Eighth international edition Moore: Clinically Oriented Anatomy – Eighth international edition". Nursing Standard. 28 (2): 1939. doi:10.7748/ns2013.09.28.2.28.s36. ISSN   0029-6570.
  6. ↑ Sinnatamby, Chummy S. (2011). Last's Anatomy (12th ed.). Elsevier Australia. ISBN   978-0-7295-3752-0.
  7. ↑ Spratt JD, Abrahams PH, Boon JM, Hutchings RT (2008). McMinn's Clinical Atlas of Human Anatomy (6th ed.). St. Louis, Mo.: Elsevier/Mosby. p. 54. ISBN   978-0-8089-2318-3.
  8. 1 2 Nanci A (2013). Ten Cate's Oral Histology: Development, Structure, and Function (8th ed.). St. Louis, Mo.: Elsevier. ISBN   978-0-323-07846-7.
  9. ↑ "The Parotid Gland". TeachMeAntatomy.info. Retrieved 11 November 2015.
  10. 1 2 3 Bath-Balogh M, Fehrenbach MJ (2011). Illustrated Dental Embryology, Histology, and Anatomy (3rd ed.). Elsevier. p. 135. ISBN   978-1-4377-1730-3.
  11. ↑ Arhakis A, Karagiannis V, Kalfas S (2013). "Salivary alpha-amylase activity and salivary flow rate in young adults". The Open Dentistry Journal. 7: 7–15. doi: 10.2174/1874210601307010007 . PMC   3601341 . PMID   23524385.
  12. ↑ Moore P (2003). The Developing Human (7th ed.). Saunders. pp. 203, 220. ISBN   978-0-8089-2265-0.
  13. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Wilson KF, Meier JD, Ward PD (June 2014). "Salivary gland disorders". American Family Physician. 89 (11): 882–88. PMID   25077394.
  14. 1 2 3 4 5 Bucur A, Dincă O, Niță T, Totan C, Vlădan C (Mar 2011). "Parotid tumors: our experience". Rev. Chir. Oro-maxilo-fac. Implantol. 2 (1): 7–9. ISSN   2069-3850. Archived from the original on January 13, 2013.(webpage has a translation button)
  15. ↑ Sivaram P, Rahul M, Jayan C, Sulfekar MS (2015). "Metastatic Malignant Phyllodes Tumour: An Interesting Presentation as a Parotid Swelling". New Indian Journal of Surgery. 6 (3): 75–77. doi:10.21088/nijs.0976.4747.6315.2. ISSN   0976-4747.
  16. ↑ Steve C Lee (22 December 2022). "Salivary Gland Neoplasms". Medscape. Updated: Jan 13, 2021
    - Image by Mikael Häggström, MD
  17. ↑ Mehanna H, McQueen A, Robinson M, Paleri V (October 2012). "Salivary gland swellings". BMJ. 345: e6794. doi:10.1136/bmj.e6794. PMID   23092898. S2CID   373247.
  18. 1 2 Iro H, Zenk J (2014-12-01). "Salivary gland diseases in children". GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery. 13: Doc06. doi:10.3205/cto000109. PMC   4273167 . PMID   25587366.
  19. ↑ Psychogios, Georgios; Bohr, Christopher; Constantinidis, Jannis; Canis, Martin; Vander Poorten, Vincent; Plzak, Jan; Knopf, Andreas; Betz, Christian; Guntinas-Lichius, Orlando; Zenk, Johannes (2020-08-04). "Review of surgical techniques and guide for decision making in the treatment of benign parotid tumors". European Archives of Oto-Rhino-Laryngology. 278 (1): 15–29. doi:10.1007/s00405-020-06250-x. ISSN   0937-4477. PMID   32749609. S2CID   220965351.
  20. ↑ Office of Rare Diseases Research (2011). "Frey's syndrome". National Institutes of Health. Retrieved 17 December 2012.
  21. 1 2 3 4 5 6 7 8 Carlson ER, Ord RA (2015). Salivary Gland Pathology: Diagnosis and Management (Second ed.). Hoboken, New Jersey: Wiley/Blackwell. ISBN   978-1-118-93375-6. OCLC   904400135.
  22. ↑ Sujatha D, Babitha K, Prasad RS, Pai A (November 2013). "Parotid lymphoepithelial cysts in human immunodeficiency virus: a review". The Journal of Laryngology and Otology. 127 (11): 1046–49. doi:10.1017/S0022215113002417. PMID   24169222. S2CID   33861207.
  23. 1 2 3 4 5 6 Anniko M, Bernal-Sprekelsen M, Bonkowsky V, Bradley P, Iurato S, eds. (2010). Otorhinolaryngology, Head and Neck Surgery. Springer. ISBN   978-3-540-42940-1.
  24. 1 2 Schlieve T, Kolokythas A, Miloro M (2015). "Chapter 14: Salary Gland Infections". In Hupp JR, Ferneini EM (eds.). Head, Neck and Orofacial Infections: An Interdisciplinary Approach. Elsevier Health Sciences. p. 235. ISBN   978-0-323-28946-7.
  25. ↑ Kumar BS, Sathasivasubramanian SP (January 2012). "The role of salivary gland scintigraphy in detection of salivary gland dysfunction in type 2 diabetic patients". Indian Journal of Nuclear Medicine. 27 (1): 16–19. doi: 10.4103/0972-3919.108832 . PMC   3628255 . PMID   23599592.
  26. ↑ "Salivary gland function scan". Johns Hopkins Sjogrens Center. Retrieved 2018-03-25.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.