CLIC6

Last updated
CLIC6
Identifiers
Aliases CLIC6 , CLIC1L, chloride intracellular channel 6
External IDs OMIM: 615321 MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6
Orthologs
SpeciesHumanMouse
Entrez

54102

209195

Ensembl

ENSG00000159212

ENSMUSG00000022949

UniProt

Q96NY7

Q8BHB9

RefSeq (mRNA)

NM_053277
NM_001317009

NM_172469

RefSeq (protein)

NP_001303938
NP_444507

NP_766057

Location (UCSC) Chr 21: 34.67 – 34.72 Mb Chr 16: 92.28 – 92.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene. [5] [6]

Contents

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3. [7]

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159212 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022949 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
  6. 1 2 "Entrez Gene: CLIC6 chloride intracellular channel 6".
  7. ↑ Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID   14499480.
  8. ↑ Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi: 10.1016/j.jbc.2023.105349 . PMC   10641671 . PMID   37838179.

Further reading

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