KCNA7

KCNA7
Identifiers
Aliases	KCNA7 , HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7
External IDs	OMIM: 176268 MGI: 96664 HomoloGene: 7791 GeneCards: KCNA7
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 49,067,418 bp [1] End 49,072,941 bp [1]
Gene ontology Molecular function • ion channel activity • potassium channel activity • voltage-gated ion channel activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cellular component • integral component of membrane • voltage-gated potassium channel complex • cell membrane • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • protein homooligomerization • ion transport • transmembrane transport • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3743	16495
Ensembl	ENSG00000104848	ENSMUSG00000038201
UniProt	Q96RP8	Q17ST2
RefSeq (mRNA)	NM_031886	NM_010596
RefSeq (protein)	NP_114092	NP_034726
Location (UCSC)	Chr 19: 49.07 – 49.07 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily A member 7 also known as K_v1.7 is a protein that in humans is encoded by the KCNA7 gene. ^[4] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000104848 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
5. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID   11343410.

Further reading

• Kashuba VI, Kvasha SM, Protopopov AI, et al. (2001). "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family". Gene. 268 (1–2): 115–22. doi:10.1016/S0378-1119(01)00423-1. PMID   11368907.
• Kalman K, Nguyen A, Tseng-Crank J, et al. (1998). "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7". J. Biol. Chem. 273 (10): 5851–7. doi: 10.1074/jbc.273.10.5851 . PMID   9488722.
• Ding Q, Zhao YY, Dong LY, et al. (2003). "[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]". Yi Chuan. 25 (2): 129–32. PMID   15639836.
• Bardien-Kruger S, Wulff H, Arieff Z, et al. (2002). "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)". Eur. J. Hum. Genet. 10 (1): 36–43. doi:10.1038/sj.ejhg.5200739. PMID   11896454. S2CID   8333189.

External links

• Kv1.7+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNA7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)