KCNG1

KCNG1
Identifiers
Aliases	KCNG1 , K13, KCNG, KV6.1, kH2, potassium voltage-gated channel modifier subfamily G member 1
External IDs	OMIM: 603788 MGI: 3616086 HomoloGene: 20515 GeneCards: KCNG1
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.13 Start 51,003,656 bp [1] End 51,023,107 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 168,102,037 bp [2] End 168,123,656 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube ganglionic eminence stromal cell of endometrium myometrium entorhinal cortex seminal vesicula cingulate gyrus amygdala prefrontal cortex optic nerve Top expressed in subiculum hippocampus proper superior frontal gyrus facial motor nucleus temporal lobe amygdala visual cortex prefrontal cortex seminiferous tubule proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport regulation of delayed rectifier potassium channel activity protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3755 241794 Ensembl ENSG00000026559 ENSMUSG00000074575 UniProt Q9UIX4 A2BDX4 RefSeq (mRNA) NM_002237 NM_172318 NM_001081134 NM_001379458 RefSeq (protein) NP_002228 NP_001074603 NP_001366387 Location (UCSC) Chr 20: 51 – 51.02 Mb Chr 2: 168.1 – 168.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily G member 1 is a protein that in humans is encoded by the KCNG1 gene. ^{[5] [6] [7]}

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Alternative splicing results in at least two transcript variants encoding distinct isoforms. ^[7]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000026559 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074575 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y (Feb 1998). "Isolation, characterization, and mapping of two human potassium channels". Biochem Biophys Res Commun. 241 (3): 675–81. doi:10.1006/bbrc.1997.7830. PMID   9434767.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
7. "Entrez Gene: KCNG1 potassium voltage-gated channel, subfamily G, member 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Post MA, Kirsch GE, Brown AM (1997). "Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current". FEBS Lett. 399 (1–2): 177–82. doi: 10.1016/S0014-5793(96)01316-6 . PMID   8980147. S2CID   5691552.

External links

• Kv6.1+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNG1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.