CACNA2D2

Last updated
CACNA2D2
Identifiers
Aliases CACNA2D2 , CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD
External IDs OMIM: 607082 MGI: 1929813 HomoloGene: 4400 GeneCards: CACNA2D2
Orthologs
SpeciesHumanMouse
Entrez

9254

56808

Ensembl

ENSG00000007402

ENSMUSG00000010066

UniProt

Q9NY47

Q6PHS9

RefSeq (mRNA)

NM_001005505
NM_001174051
NM_001291101
NM_006030

NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263

Contents

RefSeq (protein)

NP_001005505
NP_001167522
NP_001278030
NP_006021

NP_001167518
NP_001167519
NP_001167520
NP_001167521
NP_064659

Location (UCSC) Chr 3: 50.36 – 50.5 Mb Chr 9: 107.28 – 107.41 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene. [5]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [5]

CACNA2D2 containing channels are blocked by amiodarone. [6]

See also

Related Research Articles

Ca<sub>v</sub>1.2 Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, L type, alpha 1C subunit is a protein that in humans is encoded by the CACNA1C gene. Cav1.2 is a subunit of L-type voltage-dependent calcium channel.

Ca<sub>v</sub>2.1 Protein-coding gene in the species Homo sapiens

Cav2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Cav2.1 plays an important role in controlling the release of neurotransmitters between neurons. It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. Different kinds of calcium channels have different isoforms (versions) of the alpha-1 subunit. Cav2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders, including familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6.

Ca<sub>v</sub>1.4 Protein-coding gene in the species Homo sapiens

Cav1.4 also known as the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene.

Ca<sub>v</sub>1.1 Mammalian protein found in Homo sapiens

Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. It is also known as CACNL1A3 and the dihydropyridine receptor.

<span class="mw-page-title-main">CACNB2</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene.

<span class="mw-page-title-main">CACNB4</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

<span class="mw-page-title-main">CACNB1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.

Ca<sub>v</sub>1.3 Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, L type, alpha 1D subunit is a protein that in humans is encoded by the CACNA1D gene. Cav1.3 channels belong to the Cav1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines (DHP).

<span class="mw-page-title-main">CACNB3</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.

<span class="mw-page-title-main">KCNMB2</span> Protein-coding gene in the species Homo sapiens

Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.

<span class="mw-page-title-main">KCNMB3</span> Protein-coding gene in the species Homo sapiens

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.

<span class="mw-page-title-main">CACNA2D1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.

<span class="mw-page-title-main">KCNMB4</span>

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.

<span class="mw-page-title-main">Calcium channel, voltage-dependent, T type, alpha 1H subunit</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene.

<span class="mw-page-title-main">CACNG1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.

<span class="mw-page-title-main">CACNA1I</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.

<span class="mw-page-title-main">CACNA1B</span> Protein-coding gene in the species Homo sapiens

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. The α1B protein, together with β and α2δ subunits forms N-type calcium channel PMID 26386135. It is a R-type calcium channel.

<span class="mw-page-title-main">CACNA1G</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene. It is one of the primary targets in the pharmacology of absence seizure.

<span class="mw-page-title-main">CACNA2D4</span>

Calcium channel, voltage-dependent, alpha 2/delta subunit 4 is a protein that in humans is encoded by the CACNA2D4 gene.

<span class="mw-page-title-main">CACNA2D3</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 .

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000007402 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010066 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".
  6. ↑ "Amiodarone". Drugbank. Retrieved 2019-05-28.

Further reading

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