CACNA2D2

CACNA2D2
Identifiers
Aliases	CACNA2D2 , CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD
External IDs	OMIM: 607082; MGI: 1929813; HomoloGene: 4400; GeneCards: CACNA2D2; OMA:CACNA2D2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,504,244 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,406,542 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; cerebellar vermis; ; superior vestibular nucleus; ; ventral tegmental area; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; vena cava; ; right hemisphere of cerebellum; ; gonad;
	Top expressed in
	lateral septal nucleus; ; habenula; ; trigeminal ganglion; ; substantia nigra; ; lateral hypothalamus; ; motor neuron; ; mammillary body; ; supraoptic nucleus; ; lobe of cerebellum; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel activity ; metal ion binding ; voltage-gated ion channel activity ; voltage-gated calcium channel activity ;
Cellular component	voltage-gated calcium channel complex ; integral component of membrane ; membrane ; plasma membrane ;
Biological process	regulation of multicellular organism growth ; regulation of insulin secretion ; regulation of ion transmembrane transport ; positive regulation of organ growth ; ion transport ; neuromuscular junction development ; calcium ion transmembrane transport ; rhythmic synaptic transmission ; calcium ion transport ; cardiac conduction ;
	Sources:Amigo / QuickGO
Orthologs
	9254
	56808
	ENSG00000007402
	ENSMUSG00000010066
	Q9NY47
	Q6PHS9
	NM_001005505 ; NM_001174051 ; NM_001291101 ; NM_006030
	NM_001174047 ; NM_001174048 ; NM_001174049 ; NM_001174050 ; NM_020263 Contents See also ; References ; Further reading ; External links ;
	NP_001005505 ; NP_001167522 ; NP_001278030 ; NP_006021
	NP_001167518 ; NP_001167519 ; NP_001167520 ; NP_001167521 ; NP_064659
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 23, 2024

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.^[5]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[5]

CACNA2D2 containing channels are blocked by amiodarone.^[6]

Related Research Articles

Calcium channel, voltage-dependent, L type, alpha 1C subunit is a protein that in humans is encoded by the CACNA1C gene. Ca_v1.2 is a subunit of L-type voltage-dependent calcium channel.

Ca<sub>v</sub>2.1 Protein found in humans

Ca_v2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Ca_v2.1 plays an important role in controlling the release of neurotransmitters between neurons. It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. Different kinds of calcium channels have different isoforms (versions) of the alpha-1 subunit. Ca_v2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders, including familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6.

Ca_v1.4 also known as the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene.

Ca_v1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. It is also known as CACNL1A3 and the dihydropyridine receptor.

Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene.

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.

Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.

Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.

Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene.

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. The α1B protein, together with β and α2δ subunits forms N-type calcium channel. It is a R-type calcium channel.

Calcium channel, voltage-dependent, alpha 2/delta subunit 4 is a protein that in humans is encoded by the CACNA2D4 gene.

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 .

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000007402 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010066 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".
↑ "Amiodarone". Drugbank. Retrieved 2019-05-28.

External links

CACNA2D2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNA2D2 genome location and CACNA2D2 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000007402 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".

[6] "Amiodarone". Drugbank. Retrieved 2019-05-28.

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CACNA2D2

Contents

See also

Related Research Articles

References

Further reading

External links