CatSper2

Last updated
CATSPER2
Identifiers
Aliases CATSPER2 , CatSper2, cation channel sperm associated 2
External IDs OMIM: 607249; MGI: 2387404; HomoloGene: 77423; GeneCards: CATSPER2; OMA:CATSPER2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282309
NM_001282310
NM_054020
NM_172095
NM_172097

Contents

NM_153075

RefSeq (protein)

NP_001269238
NP_001269239
NP_742093

n/a

Location (UCSC) Chr 15: 43.63 – 43.67 Mb Chr 2: 121.22 – 121.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene. [5] [6] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells. [7]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. [8]

See also

Related Research Articles

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166762 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033486 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi: 10.1073/pnas.221454998 . PMC   60087 . PMID   11675491.
  6. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID   16382101. S2CID   35096827.
  7. "Entrez Gene: CatSper2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.