CatSper2

Last updated
CATSPER2
Identifiers
Aliases CATSPER2 , CatSper2, cation channel sperm associated 2
External IDs OMIM: 607249 MGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282309
NM_001282310
NM_054020
NM_172095
NM_172097

Contents

NM_153075

RefSeq (protein)

NP_001269238
NP_001269239
NP_742093

n/a

Location (UCSC) Chr 15: 43.63 – 43.67 Mb Chr 2: 121.39 – 121.41 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene. [5] [6] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells. [7]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. [8]

See also

Related Research Articles

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

Ruthenium red Chemical compound

The inorganic dye ammoniated ruthenium oxychloride, also known as ruthenium red, is used in histology to stain aldehyde fixed mucopolysaccharides.

TRPC4

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

TRPM4

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.

Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.

KCNN4

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.

ASIC3

Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1998. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

KCNMB2

Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.

CNGB1

Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein.

Cyclic nucleotide-gated channel alpha 2

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.

KCNMB4

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.

Cyclic nucleotide-gated channel alpha 4

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.

TPCN1

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments, TPCN1 only contains two domains.

TPCN2

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments, TPCN1 only contains two domain.

MCOLN3

Mucolipin-3 also known as TRPML3 is a protein that in humans is encoded by the MCOLN3 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

CatSper1

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.

CatSper3

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene. CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.

CatSper4

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.

ADCY10

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.

HVCN1

Voltage-gated hydrogen channel 1 is a protein that in humans is encoded by the HVCN1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166762 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033486 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi: 10.1073/pnas.221454998 . PMC   60087 . PMID   11675491.
  6. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID   16382101. S2CID   35096827.
  7. "Entrez Gene: CatSper2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.