Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene. [5]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells). [5]
CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms. [6]
Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.
Wiskott-Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.
H+/Cl− exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.
Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.
Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.
EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene belonging to the EHD protein family.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.
Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.
Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.
Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.
BET1 homolog is a protein that in humans is encoded by the BET1 gene.
Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene.
Ankyrin 1, also known as ANK-1, and erythrocyte ankyrin, is a protein that in humans is encoded by the ANK1 gene.
Chloride intracellular channel protein 3 is a protein that in humans is encoded by the CLIC3 gene. This protein is a chloride channel.
Ankyrin-3 (ANK-3), also known as ankyrin-G, is a protein from ankyrin family that in humans is encoded by the ANK3 gene.
Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.
Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.