CatSper1

CATSPER1
Identifiers
Aliases	CATSPER1 , CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDs	OMIM: 606389; MGI: 2179947; HomoloGene: 14207; GeneCards: CATSPER1; OMA:CATSPER1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 66,016,752 bp [1] End 66,026,479 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 5,385,769 bp [2] End 5,394,308 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte granulocyte left testis right testis Descending thoracic aorta ascending aorta blood popliteal artery tibial arteries Top expressed in seminiferous tubule spermatid spermatocyte islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function calcium activated cation channel activity calcium channel activity voltage-gated ion channel activity ion channel activity protein binding high voltage-gated calcium channel activity voltage-gated calcium channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium motile cilium Biological process cell differentiation membrane depolarization during action potential regulation of ion transmembrane transport ion transport multicellular organism development calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition calcium ion transport flagellated sperm motility regulation of cilium beat frequency involved in ciliary motility response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117144 225865 Ensembl ENSG00000175294 ENSMUSG00000038498 UniProt Q8NEC5 Q91ZR5 RefSeq (mRNA) NM_053054 NM_139301 RefSeq (protein) NP_444282 NP_647462 Location (UCSC) Chr 11: 66.02 – 66.03 Mb Chr 19: 5.39 – 5.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene. ^{[5] [6] [7]} CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells. ^[8]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000175294 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038498 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi: 10.1073/pnas.221454998 . PMC   60087 . PMID   11675491.
6. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. Bibcode:2001Natur.413..603R. doi:10.1038/35098027. PMC   8462998 . PMID   11595941. S2CID   4424815.
7. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID   16382101. S2CID   35096827.
8. "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-05. Retrieved 2008-12-16.
9. "Entrez Gene: CatSper1".

Further reading

• Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa". Asian J. Androl. 8 (3): 301–6. doi: 10.1111/j.1745-7262.2006.00132.x . PMID   16625279.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi: 10.1074/jbc.M511288200 . PMID   16740636.
• Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein". Am. J. Hum. Genet. 84 (4): 505–10. doi:10.1016/j.ajhg.2009.03.004. PMC   2667975 . PMID   19344877.
• Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. Bibcode:2001Natur.413..579G. doi:10.1038/35098164. PMID   11595929. S2CID   6099942.
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi: 10.1073/pnas.221454998 . PMC   60087 . PMID   11675491.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID   16382101. S2CID   35096827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility". Hum. Reprod. 19 (1): 124–8. doi:10.1093/humrep/deh043. PMID   14688170.
• Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. Bibcode:2001Natur.413..603R. doi:10.1038/35098027. PMC   8462998 . PMID   11595941. S2CID   4424815.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.