CACNA1I

CACNA1I
Identifiers
Aliases	CACNA1I , Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDs	OMIM: 608230; MGI: 2178051; HomoloGene: 69331; GeneCards: CACNA1I; OMA:CACNA1I - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 39,570,753 bp [1] End 39,689,735 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 80,171,439 bp [2] End 80,282,480 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 primary visual cortex middle temporal gyrus Brodmann area 46 entorhinal cortex Region I of hippocampus proper postcentral gyrus superior frontal gyrus glutes right frontal lobe Top expressed in striatum of neuraxis olfactory bulb superior frontal gyrus visual cortex primary visual cortex cerebellum dentate gyrus of hippocampal formation granule cell cerebellar cortex hippocampus proper hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated calcium channel activity calcium channel activity low voltage-gated calcium channel activity voltage-gated ion channel activity ion channel activity protein binding voltage-gated sodium channel activity Cellular component voltage-gated calcium channel complex integral component of membrane membrane plasma membrane Biological process flagellated sperm motility membrane depolarization during action potential calcium ion import regulation of ion transmembrane transport ion transport positive regulation of calcium ion-dependent exocytosis sleep calcium ion transmembrane transport transmembrane transport calcium ion transport signal transduction neuronal action potential sodium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8911 239556 Ensembl ENSG00000100346 ENSMUSG00000022416 UniProt Q9P0X4 n/a RefSeq (mRNA) NM_001003406 NM_021096 NM_001044308 RefSeq (protein) NP_001003406 NP_066919 n/a Location (UCSC) Chr 22: 39.57 – 39.69 Mb Chr 15: 80.17 – 80.28 Mb PubMed search [3] [4]
Wikidata
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Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Ca_v3.3 is a protein which in humans is encoded by the CACNA1I gene. ^{[5] [6] [7]}

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. ^[5]

See also

• T-type calcium channel

References

1. GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
6. Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi: 10.1016/S0304-3940(99)00319-5 . PMID   10454147. S2CID   140208155.
7. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID   16382099. S2CID   10386627.

External links

• CACNA1i+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CACNA1I genome location and CACNA1I gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.