CACNA1I

Last updated
CACNA1I
Identifiers
Aliases CACNA1I , Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDs OMIM: 608230 MGI: 2178051 HomoloGene: 69331 GeneCards: CACNA1I
Orthologs
SpeciesHumanMouse
Entrez

8911

239556

Ensembl

ENSG00000100346

ENSMUSG00000022416

UniProt

Q9P0X4

n/a

RefSeq (mRNA)

NM_001003406
NM_021096

NM_001044308

RefSeq (protein)

NP_001003406
NP_066919

n/a

Location (UCSC) Chr 22: 39.57 – 39.69 Mb Chr 15: 80.17 – 80.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene. [5] [6] [7]

Contents

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. [5]

See also

Related Research Articles

Ca<sub>v</sub>1.2 Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, L type, alpha 1C subunit is a protein that in humans is encoded by the CACNA1C gene. Cav1.2 is a subunit of L-type voltage-dependent calcium channel.

Ca<sub>v</sub>2.1 Protein-coding gene in the species Homo sapiens

Cav2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Cav2.1 plays an important role in controlling the release of neurotransmitters between neurons. It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. Different kinds of calcium channels have different isoforms (versions) of the alpha-1 subunit. Cav2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders, including familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6.

Ca<sub>v</sub>1.4 Protein-coding gene in the species Homo sapiens

Cav1.4 also known as the calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene.

Ca<sub>v</sub>1.1 Mammalian protein found in Homo sapiens

Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. It is also known as CACNL1A3 and the dihydropyridine receptor.

<span class="mw-page-title-main">CACNB2</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-2 is a protein that in humans is encoded by the CACNB2 gene.

<span class="mw-page-title-main">CACNB4</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

<span class="mw-page-title-main">CACNB1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.

<span class="mw-page-title-main">CACNG2</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.

<span class="mw-page-title-main">CACNB3</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.

<span class="mw-page-title-main">CACNA2D1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.

<span class="mw-page-title-main">CACNG3</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.

<span class="mw-page-title-main">KCNMB4</span>

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.

<span class="mw-page-title-main">Calcium channel, voltage-dependent, T type, alpha 1H subunit</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1H subunit, also known as CACNA1H, is a protein which in humans is encoded by the CACNA1H gene.

<span class="mw-page-title-main">CACNG4</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.

<span class="mw-page-title-main">CACNG1</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.

<span class="mw-page-title-main">CACNA2D2</span> Protein-coding gene in the species Homo sapiens

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.

<span class="mw-page-title-main">CACNA1B</span> Protein-coding gene in the species Homo sapiens

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene. The α1B protein, together with β and α2δ subunits forms N-type calcium channel PMID 26386135. It is a R-type calcium channel.

<span class="mw-page-title-main">CACNA1G</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene. It is one of the primary targets in the pharmacology of absence seizure.

<span class="mw-page-title-main">CACNA2D4</span>

Calcium channel, voltage-dependent, alpha 2/delta subunit 4 is a protein that in humans is encoded by the CACNA2D4 gene.

<span class="mw-page-title-main">CACNA2D3</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 is a protein that in humans is encoded by the CACNA2D3 gene on chromosome 3 .

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100346 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022416 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
  6. ↑ Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi: 10.1016/S0304-3940(99)00319-5 . PMID   10454147. S2CID   140208155.
  7. ↑ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID   16382099. S2CID   10386627.

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