KCNJ14

KCNJ14
Identifiers
Aliases	KCNJ14 , IRK4, KIR2.4, potassium voltage-gated channel subfamily J member 14, potassium inwardly rectifying channel subfamily J member 14
External IDs	OMIM: 603953; MGI: 2384820; HomoloGene: 27086; GeneCards: KCNJ14; OMA:KCNJ14 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 48,455,574 bp [1] End 48,466,980 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 45,465,884 bp [2] End 45,474,206 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen stromal cell of endometrium gastrocnemius muscle skin of leg primary visual cortex ventricular zone skin of abdomen muscle of thigh caudate nucleus skeletal muscle tissue Top expressed in layer of retina neural layer of retina anterior horn of spinal cord eyelid olfactory cortex spinal ganglia lower eyelid Amygdala upper eyelid trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity inward rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex soma plasma membrane dendrite membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3770 211480 Ensembl ENSG00000182324 ENSMUSG00000058743 UniProt Q9UNX9 Q8JZN3 RefSeq (mRNA) NM_170720 NM_013348 NM_145963 RefSeq (protein) NP_037480 NP_666075 Location (UCSC) Chr 19: 48.46 – 48.47 Mb Chr 7: 45.47 – 45.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as K_ir2.4, is a human gene. ^[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene. ^[5]

See also

• Inward-rectifier potassium ion channel

References

1. GRCh38: Ensembl release 89: ENSG00000182324 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058743 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14".

Further reading

• Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID   16382105. S2CID   11588492.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Töpert C, Döring F, Wischmeyer E, et al. (1998). "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei". J. Neurosci. 18 (11): 4096–105. doi: 10.1523/JNEUROSCI.18-11-04096.1998 . PMC   6792806 . PMID   9592090.
• Töpert C, Döring F, Derst C, et al. (2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)". Mamm. Genome. 11 (3): 247–9. doi:10.1007/s003350010047. hdl: 11858/00-001M-0000-0012-F99D-B . PMID   10723734. S2CID   7544438.
• Hughes BA, Kumar G, Yuan Y, et al. (2000). "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. doi:10.1152/ajpcell.2000.279.3.C771. PMID   10942728.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi: 10.1093/dnares/8.6.319 . PMID   11853319.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fang Y, Schram G, Romanenko VG, et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID   15958527. S2CID   11840480.
• Tennant BP, Cui Y, Tinker A, Clapp LH (2007). "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits". J. Membr. Biol. 213 (1): 19–29. doi:10.1007/s00232-006-0037-y. PMC   1973150 . PMID   17347781.

External links

• KCNJ14+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.