KCNK6

KCNK6
Identifiers
Aliases	KCNK6 , K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939 MGI: 1891291 HomoloGene: 31266 GeneCards: KCNK6
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 38,319,845 bp [1] End 38,332,076 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B1|7 16.94 cM Start 28,921,351 bp [2] End 28,931,940 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right coronary artery ascending aorta myometrium vagina smooth muscle tissue parotid gland left coronary artery skin of abdomen cavity of mouth Top expressed in fossa skin of abdomen right lobe of liver Epithelium of stomach Paneth cell parotid gland condyle belly cord calvaria left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inward rectifier potassium channel activity voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane integral component of plasma membrane Biological process regulation of resting membrane potential potassium ion transport regulation of ion transmembrane transport cardiac conduction ion transport negative regulation of systemic arterial blood pressure potassium ion transmembrane transport regulation of systemic arterial blood pressure stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9424 52150 Ensembl ENSG00000099337 ENSMUSG00000046410 UniProt Q9Y257 n/a RefSeq (mRNA) NM_004823 NM_001033525 RefSeq (protein) NP_004814 NP_004814.1 n/a Location (UCSC) Chr 19: 38.32 – 38.33 Mb Chr 7: 28.92 – 28.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene. ^{[5] [6] [7] [8]}

This gene encodes K_2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. ^[8]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000099337 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046410 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi: 10.1074/jbc.274.12.7887 . PMID   10075682.
6. Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID   10393428. S2CID   84538070.
7. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106. S2CID   7356601.
8. "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

Further reading

• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID   11256078. S2CID   9682396.
• Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management". Gastrointestinal Radiology. 1 (2): 167–71. doi:10.1007/BF02256360. PMID   1088718. S2CID   12318832.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi: 10.1074/jbc.274.17.11751 . PMID   10206991.
• Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit". FEBS Lett. 450 (3): 191–6. doi: 10.1016/S0014-5793(99)00495-0 . PMID   10359073. S2CID   42980921.
• Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel". J. Biol. Chem. 275 (37): 28722–30. doi: 10.1074/jbc.M003755200 . PMID   10887187.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4". J. Neurosci. Res. 75 (1): 25–31. doi:10.1002/jnr.10839. PMID   14689445. S2CID   19133204.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• KCNK6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.