KCNJ9

KCNJ9
Identifiers
Aliases	KCNJ9 , GIRK3, KIR3.3, potassium voltage-gated channel subfamily J member 9, potassium inwardly rectifying channel subfamily J member 9
External IDs	OMIM: 600932; MGI: 108007; HomoloGene: 37989; GeneCards: KCNJ9; OMA:KCNJ9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 160,081,538 bp [1] End 160,090,563 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.66 cM Start 172,148,068 bp [2] End 172,156,885 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 primary visual cortex right hemisphere of cerebellum right frontal lobe lateral nuclear group of thalamus dorsolateral prefrontal cortex superior frontal gyrus prefrontal cortex postcentral gyrus Top expressed in cerebellar vermis medial dorsal nucleus lateral geniculate nucleus lobe of cerebellum neural layer of retina medial geniculate nucleus cingulate gyrus primary motor cortex perirhinal cortex entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding inward rectifier potassium channel activity voltage-gated ion channel activity G-protein activated inward rectifier potassium channel activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane parallel fiber to Purkinje cell synapse integral component of presynaptic membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3765 16524 Ensembl ENSG00000162728 ENSMUSG00000038026 UniProt Q92806 P48543 RefSeq (mRNA) NM_004983 NM_008429 NM_001360808 RefSeq (protein) NP_004974 NP_032455 NP_001347737 Location (UCSC) Chr 1: 160.08 – 160.09 Mb Chr 1: 172.15 – 172.16 Mb PubMed search [3] [4]
Wikidata
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G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene. ^{[5] [6] [7]}

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. ^[7]

Interactions

KCNJ9 has been shown to interact with KCNJ6. ^{[8] [9]}

See also

• G protein-coupled inwardly-rectifying potassium channel
• Inward-rectifier potassium ion channel

References

1. GRCh38: Ensembl release 89: ENSG00000162728 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038026 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG (Oct 1995). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics. 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID   8575783.
6. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID   16382105. S2CID   11588492.
7. "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9".
8. Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi: 10.1074/jbc.M007087200 . PMID   10956667.
9. Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi: 10.1074/jbc.M205035200 . PMID   12297500.

Further reading

• Jelacic TM, Sims SM, Clapham DE (May 1999). "Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3". The Journal of Membrane Biology. 169 (2): 123–9. doi:10.1007/s002329900524. PMID   10341034. S2CID   13538678.
• Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH (Dec 1999). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID   10659995.
• Vaughn J, Wolford JK, Prochazka M, Permana PA (Aug 2000). "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)". Biochemical and Biophysical Research Communications. 274 (2): 302–9. doi:10.1006/bbrc.2000.3136. PMID   10913335.
• Jelacic TM, Kennedy ME, Wickman K, Clapham DE (Nov 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". The Journal of Biological Chemistry. 275 (46): 36211–6. doi: 10.1074/jbc.M007087200 . PMID   10956667.
• Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (Nov 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi: 10.1074/jbc.M205035200 . PMID   12297500.
• Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi: 10.1186/1471-2407-5-104 . PMC   1208863 . PMID   16109170.

External links

• KCNJ9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.