Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. [5] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6). [6] [7] [8]
The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories. [9] [10] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands. Only a single voltage sensor domain appears to responsible for voltage sensing.
Genetic knockout and pharmacological inhibition experiments demonstrate that the two-pore channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice. [11]
Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.
Probable G-protein coupled receptor 157 is a protein that in humans is encoded by the GPR157 gene.
SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.
Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.
Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.
Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.
Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene. CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.
KIAA0999 protein is a protein that in humans is encoded by the SIK3 gene.
Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.
Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene.
Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.
Protein LMBR1L is a protein that in humans is encoded by the LMBR1L gene.
Centrosomal protein of 72 kDa is a protein that in humans is encoded by the CEP72 gene.
Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene.
Potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.
Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments, TPCN1 only contains two domain.
Potassium channel subfamily T, member 1, also known as KCNT1 is a human gene that encodes the KCa4.1 protein. KCa4.1 is a member of the calcium-activated potassium channel protein family
Kelch-like protein 3 is a protein in humans that is encoded by the KLHL3 gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
