KCND1

KCND1
Identifiers
Aliases	KCND1 , KV4.1, potassium voltage-gated channel subfamily D member 1
External IDs	OMIM: 300281; MGI: 96671; HomoloGene: 21035; GeneCards: KCND1; OMA:KCND1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.23 Start 48,961,378 bp [1] End 48,971,844 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X A1.1|X 3.53 cM Start 7,688,528 bp [2] End 7,704,519 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right hemisphere of cerebellum left uterine tube stromal cell of endometrium Descending thoracic aorta paraflocculus of cerebellum ascending aorta left coronary artery granulocyte gallbladder Top expressed in lumbar spinal ganglion facial motor nucleus granulocyte gastrula tail of embryo anterior horn of spinal cord genital tubercle superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel activity metal ion binding voltage-gated ion channel activity ion channel activity A-type (transient outward) potassium channel activity voltage-gated potassium channel activity Cellular component integral component of membrane cell projection membrane voltage-gated potassium channel complex plasma membrane neuronal cell body dendrite cellular component Biological process regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3750 16506 Ensembl ENSG00000102057 ENSMUSG00000009731 UniProt Q9NSA2 Q03719 RefSeq (mRNA) NM_004979 NM_008423 RefSeq (protein) NP_004970 NP_032449 Location (UCSC) Chr X: 48.96 – 48.97 Mb Chr X: 7.69 – 7.7 Mb PubMed search [3] [4]
Wikidata
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Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene. ^[5]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. ^[5]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000102057 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009731 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1".

Further reading

• Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.
• Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. doi: 10.1523/JNEUROSCI.19-18-07770.1999 . PMC   6782450 . PMID   10479680.
• Isbrandt D, Leicher T, Waldschütz R, et al. (2000). "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)". Genomics. 64 (2): 144–54. doi:10.1006/geno.2000.6117. PMID   10729221.
• Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–9. Bibcode:2001FEBSL.499..205N. doi: 10.1016/S0014-5793(01)02560-1 . PMID   11423117.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Jerng HH, Qian Y, Pfaffinger PJ (2005). "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)". Biophys. J. 87 (4): 2380–96. doi:10.1529/biophysj.104.042358. PMC   1304660 . PMID   15454437.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kim SJ, Choi WS, Han JS, et al. (2005). "A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis". J. Biol. Chem. 280 (31): 28692–700. doi: 10.1074/jbc.M504913200 . PMID   15955806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.