KCNT1

KCNT1
Identifiers
Aliases	KCNT1 , EIEE14, ENFL5, KCa4.1, SLACK, bA100C15.2, Slo2.2, potassium sodium-activated channel subfamily T member 1, DEE14
External IDs	OMIM: 608167; MGI: 1924627; HomoloGene: 11055; GeneCards: KCNT1; OMA:KCNT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	135,795,508 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,808,285 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; gastrocnemius muscle; ; putamen; ; muscle of thigh; ; prefrontal cortex; ; caudate nucleus; ; spleen;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; primary visual cortex; ; lobe of cerebellum; ; cerebellar vermis; ; olfactory tubercle; ; superior colliculus; ; inferior colliculi; ; central gray substance of midbrain; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated potassium channel activity ; potassium channel activity ; calcium-activated potassium channel activity ; intracellular sodium activated potassium channel activity ; outward rectifier potassium channel activity ;
Cellular component	integral component of membrane ; voltage-gated potassium channel complex ; plasma membrane ; membrane ;
Biological process	potassium ion transport ; ion transport ; potassium ion transmembrane transport ; regulation of membrane potential ;
	Sources:Amigo / QuickGO
Orthologs
	57582
	227632
	ENSG00000107147
	ENSMUSG00000058740
	Q5JUK3
	Q6ZPR4
	NM_001272003 ; NM_020822
	NM_001145403 ; NM_175462 ; NM_001302351
	NP_001258932 ; NP_065873
	NP_001138875 ; NP_001289280 ; NP_780671
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 23, 2025

Potassium channel subfamily T, member 1, also known as KCNT1 is a human gene that encodes the K_Ca4.1 protein. K_Ca4.1 is a member of the calcium-activated potassium channel protein family ^[5]

Associated Conditions

Mutations in the KCNT1 gene has been shown to be a cause of Ohtahara syndrome and other congenital neurodegenerative diseases. ^[6]

Related Research Articles

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.

Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the K_Ca2.1 protein.

Potassium voltage-gated channel, subfamily H (eag-related), member 5, also known as KCNH5, is a human gene encoding the K_v10.2 protein.

Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as K_v4.1, is a human gene.

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.

Potassium voltage-gated channel subfamily G member 1 is a protein that in humans is encoded by the KCNG1 gene.

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the KCNH6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.

Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the K_Na protein. KCNT2, also known as the Slick channel is an outwardly rectifying potassium channel activated by internal raises in sodium or chloride ions.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107147 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058740 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: KCNT1 potassium channel, subfamily T, member 1".
↑ "OMIM: 614959".{{cite web}}: Missing or empty |url= (help)

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107147 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KCNT1 potassium channel, subfamily T, member 1".

[6] "OMIM: 614959".{{cite web}}: Missing or empty |url= (help)

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KCNT1

Contents

Associated Conditions

See also

Related Research Articles

References

Further reading