KCNB2

KCNB2
Identifiers
Aliases	KCNB2 , KV2.2, potassium voltage-gated channel subfamily B member 2
External IDs	OMIM: 607738 MGI: 99632 HomoloGene: 31263 GeneCards: KCNB2
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.11 Start 72,537,225 bp [1] End 72,938,349 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 A3|1 4.5 cM Start 15,357,478 bp [2] End 15,793,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans ganglionic eminence prefrontal cortex Brodmann area 23 dorsolateral prefrontal cortex Brodmann area 9 entorhinal cortex middle temporal gyrus superior frontal gyrus Brodmann area 46 Top expressed in olfactory bulb ganglionic eminence neural tube mesencephalon hippocampus proper secondary oocyte spinal ganglia hypothalamus rhombencephalon superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity ion channel activity protein heterodimerization activity voltage-gated potassium channel activity Cellular component perikaryon cell projection membrane voltage-gated potassium channel complex plasma membrane neuronal cell body membrane dendrite integral component of membrane neuronal cell body Biological process regulation of smooth muscle contraction regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport protein homooligomerization potassium ion transmembrane transport protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9312 98741 Ensembl ENSG00000182674 ENSMUSG00000092083 UniProt Q92953 A6H8H5 RefSeq (mRNA) NM_004770 NM_001033195 NM_001098528 RefSeq (protein) NP_004761 NP_001091998 Location (UCSC) Chr 8: 72.54 – 72.94 Mb Chr 1: 15.36 – 15.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene. ^{[5] [6]} The protein encoded by this gene is a voltage-gated potassium channel subunit. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000182674 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000092083 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, et al. (May 1998). "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles". The American Journal of Physiology. 274 (5): G901–G911. doi:10.1152/ajpgi.1998.274.5.G901. PMID   9612272.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Färkkilä M, et al. (November 2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Human Molecular Genetics. 17 (21): 3318–3331. doi:10.1093/hmg/ddn227. PMC   2566523 . PMID   18676988.
• Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, et al. (March 2004). "Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes. 53 (3): 597–607. doi: 10.2337/diabetes.53.3.597 . PMID   14988243.
• Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, et al. (July 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". The EMBO Journal. 15 (13): 3322–3331. doi:10.1002/j.1460-2075.1996.tb00697.x. PMC   451895 . PMID   8670833.
• Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, et al. (February 2009). "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Human Molecular Genetics. 18 (4): 767–778. doi:10.1093/hmg/ddn388. PMC   4334814 . PMID   19010793.
• Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell GF, Kathiresan S, et al. (September 2007). "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Medical Genetics. 8 Suppl 1: S2. doi:10.1186/1471-2350-8-S1-S2. PMC   1995617 . PMID   17903301.
• Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, et al. (June 2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–1785. doi:10.1002/pmic.200601006. PMID   17474147. S2CID   22474278.
• Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP (March 1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". The Journal of Biological Chemistry. 272 (13): 8774–8780. doi: 10.1074/jbc.272.13.8774 . PMID   9079713.

External links

• Kv2.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)