KCNAB3

KCNAB3
Identifiers
Aliases	KCNAB3 , AKR6A9, KCNA3.1B, KCNA3B, KV-BETA-3, potassium voltage-gated channel subfamily A regulatory beta subunit 3
External IDs	OMIM: 604111; MGI: 1336208; HomoloGene: 55844; GeneCards: KCNAB3; OMA:KCNAB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 7,921,859 bp [1] End 7,929,856 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 69,217,084 bp [2] End 69,223,868 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum body of uterus ventricular zone right frontal lobe ganglionic eminence anterior cingulate cortex left uterine tube granulocyte Brodmann area 9 prefrontal cortex Top expressed in inferior colliculus lumbar subsegment of spinal cord primary visual cortex superior frontal gyrus cerebellar cortex neural layer of retina medial vestibular nucleus medial geniculate nucleus deep cerebellar nuclei lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity potassium channel regulator activity voltage-gated ion channel activity Cellular component cytoplasm integral component of membrane plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9196 16499 Ensembl ENSG00000170049 ENSMUSG00000018470 UniProt O43448 P97382 RefSeq (mRNA) NM_004732 NM_010599 RefSeq (protein) NP_004723 n/a Location (UCSC) Chr 17: 7.92 – 7.93 Mb Chr 11: 69.22 – 69.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Voltage-gated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNAB3 gene. ^[5] The protein encoded by this gene is a voltage-gated potassium channel beta subunit. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000170049 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018470 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leicher T, Bahring R, Isbrandt D, Pongs O (Feb 1999). "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel". J Biol Chem. 273 (52): 35095–101. doi: 10.1074/jbc.273.52.35095 . PMID   9857044.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• McCormack K, McCormack T, Tanouye M, et al. (1995). "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product". FEBS Lett. 370 (1–2): 32–6. Bibcode:1995FEBSL.370...32M. doi:10.1016/0014-5793(95)00785-8. PMID   7649300. S2CID   83802327.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• KCNAB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)