KCNK17

KCNK17
Identifiers
Aliases	KCNK17 , K2p17.1, TALK-2, TALK2, TASK-4, TASK4, potassium two pore domain channel subfamily K member 17
External IDs	OMIM: 607370; HomoloGene: 88928; GeneCards: KCNK17; OMA:KCNK17 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.2 Start 39,299,001 bp [1] End 39,314,461 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta Descending thoracic aorta right coronary artery islet of Langerhans left coronary artery right lung upper lobe of lung upper lobe of left lung lower lobe of lung tibia n/a More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89822 n/a Ensembl ENSG00000124780 n/a UniProt Q96T54 n/a RefSeq (mRNA) NM_001135111 NM_031460 n/a RefSeq (protein) NP_001128583 NP_113648 n/a Location (UCSC) Chr 6: 39.3 – 39.31 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene. ^{[3] [4]}

This gene encodes K_2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH. ^[4]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000124780 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID   16382106. S2CID   7356601.
4. "Entrez Gene: KCNK17 potassium channel, subfamily K, member 17".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID   11263999.
• Decher N, Maier M, Dittrich W, et al. (2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family". FEBS Lett. 492 (1–2): 84–9. Bibcode:2001FEBSL.492...84D. doi:10.1016/S0014-5793(01)02222-0. PMID   11248242. S2CID   23620127.

External links

• KCNK17+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.