KCNH4

KCNH4
Identifiers
Aliases	KCNH4 , BEC2, ELK1, Kv12.3, potassium voltage-gated channel subfamily H member 4
External IDs	OMIM: 604528 MGI: 2156184 HomoloGene: 8180 GeneCards: KCNH4
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 42,156,891 bp [1] End 42,181,142 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 63.57 cM Start 100,631,202 bp [2] End 100,650,768 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus nucleus accumbens prefrontal cortex Brodmann area 9 appendix amygdala urinary bladder hypothalamus lymph node Top expressed in superior frontal gyrus mesencephalon olfactory bulb neural tube ganglionic eminence hypothalamus rhombencephalon hippocampus proper white adipose tissue kidney More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity ion channel activity phosphorelay sensor kinase activity potassium channel activity voltage-gated potassium channel activity Cellular component integral component of membrane intracellular anatomical structure plasma membrane voltage-gated potassium channel complex membrane integral component of plasma membrane Biological process ion transport phosphorelay signal transduction system signal transduction potassium ion transmembrane transport potassium ion transport regulation of ion transmembrane transport transmembrane transport regulation of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23415 380728 Ensembl ENSG00000089558 ENSMUSG00000035355 UniProt Q9UQ05 A2A5F7 RefSeq (mRNA) NM_012285 NM_001081194 RefSeq (protein) NP_036417 NP_001074663 Location (UCSC) Chr 17: 42.16 – 42.18 Mb Chr 11: 100.63 – 100.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily H member 4 is a protein that in humans is encoded by the KCNH4 gene. ^{[5] [6]} The protein encoded by this gene is a voltage-gated potassium channel subunit. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000089558 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035355 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi: 10.1074/jbc.274.35.25018 . PMID   10455180.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID   16382104. S2CID   219195192.

Further reading

• Zou A, Lin Z, Humble M, et al. (2003). "Distribution and functional properties of human KCNH8 (Elk1) potassium channels". Am. J. Physiol., Cell Physiol. 285 (6): C1356–66. CiteSeerX   10.1.1.196.6556 . doi:10.1152/ajpcell.00179.2003. PMID   12890647. S2CID   39591842.

External links

• Kv12.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNH4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)