Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.
Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.
It is the only aquaporin regulated by vasopressin. [5] The basic job of aquaporin 2 is to reabsorb water from the primary urine that flows into the nephron from the filtration of blood in the glomerulus through the Bowman's capsule. [6] Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed, vasopressin binds to the cell surface vasopressin receptor thereby activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane, so the aquaporin 2 can be used by the cell. [7] This aquaporin is regulated in two ways by the peptide hormone vasopressin:
This aquaporin is also regulated by food intake. Fasting reduces expression of this aquaporin independently of vasopressin.
Mutations in this channel are associated with nephrogenic diabetes insipidus, which can be autosomal dominant or recessive. Mutations in the vasopressin receptor cause a similar X-linked phenotype.
Lithium, which is often used to treat bipolar disorder, can cause acquired diabetes insipidus (characterized by the excretion of large volumes of dilute urine) by decreasing the expression of the AQP2 gene.
The expression of the AQP2 gene is increased during conditions associated with water retention such as pregnancy and congestive heart failure.